{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T09:04:50Z","timestamp":1766653490088,"version":"3.48.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2024-0103_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Phosphorus, an essential mineral with diverse biological functions, has recently garnered attention for its potential role in modulating the immune system. However, no study is present regarding the effect of homoepthic preparation of Phosphorus on immune system. Thus, this study aims to investigate the immunomodulatory effects of Phosphorus, shedding light on its impact on Normal and Immunosuppressive conditions in\u00a0mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0103_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The immunomodulatory effect of Phosphorus 6C, 30C, and 200C was tested using Sheep red blood cells on humoral antibody titer and delayed-type hypersensitivity assays. The effect of Phosphorus was investigated in cyclophosphamide induced immune-compromised mice by assessing hematology, organ index, phagocytic index, histology, cytokine level, and their mRNA expression in the spleen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0103_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phosphorus 6C produced a significant increase in the primary and secondary humoral immune response. While Phosphorus treatment at 6C, 30C, and 200C did not significantly alter hematological and organ index parameters, it considerably enhance the phagocytic index at 30C and 200C, and raise the levels of TNF-\u03b1 and IL-2 in mice against immunosuppression induced by CPM after the pretreatment with Phosphorus-30C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0103_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study shows that Phosphorus 6C potency augment the humoral immunity. In case of immunosuppression, Phosphorus at high dilution might play a significant role but more research is needed to find out the possible effect of Phosphorus preparation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2024-0103","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T18:22:03Z","timestamp":1745864523000},"page":"131-141","source":"Crossref","is-referenced-by-count":2,"title":["Immunomodulatory potential of phosphorus: insights from experimental mice models under normal and immunosuppressive condition"],"prefix":"10.1515","volume":"40","author":[{"given":"Sangita","family":"Behera","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Drug Standardization Unit , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Drug Standardization Unit , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj Kumar","family":"Regar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Drug Standardization Unit , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-7869","authenticated-orcid":false,"given":"Pankaj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Drug Standardization Unit , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheen","family":"Jabbar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Drug Standardization Unit , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godlaveti Vijay Narasimha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Dr Anjali Chatterji- Regional Research Institute for Homoeopathy , Kolkata , West Bengal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satvinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory , DDPR-Central Research Institute for Homoeopathy , Noida , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"2025121207003510770_j_dmpt-2024-0103_ref_001","doi-asserted-by":"crossref","unstructured":"Garofalo, S, Cocozza, G, Porzia, A, Inghilleri, M, Raspa, M, Scavizzi, F, et al.. 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