{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:46:55Z","timestamp":1765525615874,"version":"3.48.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Eczema coxsackium (EC) can manifest in patients with underlying atopic dermatitis (AD) as a diffuse vesicular rash in a febrile child. The presentation overlaps clinically with the feared diagnosis of eczema herpeticum (EH), which makes differentiating between the conditions very important.<\/jats:p>\n <\/jats:sec>\n \n Case presentation:<\/jats:title>\n A 6-month-old girl with known AD presented with fever and rapidly spreading vesicular rash. The patient had multiple exposures including a new antibiotic prescription, introduction of new foods, 6-month vaccinations and a sick contact. She was treated empirically with acyclovir for EH until herpes simplex virus (HSV) polymerase chain reaction (PCR) returned negative and enterovirus PCR returned positive. Once the diagnosis of EC was confirmed, antiviral therapy was discontinued and she was treated successfully with supportive measures without sequelae.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Differentiating EC from EH is important clinically as EC is self-limiting and resolves spontaneously whereas EH may cause severe complications if not treated early. While morphology alone cannot reliably distinguish between the conditions, clinical suspicion based on history can prompt proper testing and improve patient outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/dx-2017-0033","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T17:16:07Z","timestamp":1511370967000},"page":"261-264","source":"Crossref","is-referenced-by-count":1,"title":["Not all that vesicles is herpes"],"prefix":"10.1515","volume":"4","author":[{"given":"Robert R.","family":"Gruhl","sequence":"first","affiliation":[{"name":"University of Minnesota Medical School , 420 Delaware St SE , Minneapolis, MN 55455 , USA , Phone: +1-219-790-3643"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , University of Minnesota Medical School , Minneapolis, MN , USA"},{"name":"Department of Medicine , University of Minnesota Medical School , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah","family":"Niermann","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospitals and Clinics of Minnesota , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , University of Minnesota Medical School , Minneapolis, MN , USA"},{"name":"Department of Medicine , University of Minnesota Medical School , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"2025121207052652605_j_dx-2017-0033_ref_001_w2aab3b7b7b1b6b1ab1b4b1Aa","doi-asserted-by":"crossref","unstructured":"Nahmias AJ. Generalized eruption in a child with eczema due to coxsackievirus A16. Arch Dermatol 1968;97:147\u20138.10.1001\/archderm.1968.01610080051008","DOI":"10.1001\/archderm.1968.01610080051008"},{"key":"2025121207052652605_j_dx-2017-0033_ref_002_w2aab3b7b7b1b6b1ab1b4b2Aa","doi-asserted-by":"crossref","unstructured":"Mathes EF, Oza V, Frieden IJ, Cordoro KM, Yagi S, Howard R, et al. \u201cEczema coxsackium\u201d and unusual cutaneous findings in an enterovirus outbreak. Pediatrics 2013;132:e149\u201357.10.1542\/peds.2012-3175","DOI":"10.1542\/peds.2012-3175"},{"key":"2025121207052652605_j_dx-2017-0033_ref_003_w2aab3b7b7b1b6b1ab1b4b3Aa","doi-asserted-by":"crossref","unstructured":"Hampton JR, Harrison MJ, Mitchell JR, Prichard JS, Seymour C. Relative contributions of history-taking, physical examination, and laboratory investigation to diagnosis and management of medical outpatients. 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