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A comprehensive overview of scientific literature leads us to conclude that hemolyzed samples are the most frequent cause of specimen non-conformity in clinical laboratories (40\u201370%), followed by insufficient or inappropriate sample volume (10\u201320%), biological samples collected in the wrong container (5\u201315%) and undue clotting (5\u201310%). Less frequent causes of impaired sample quality include contamination by infusion fluids (i.e. most often saline or glucose solutions), cross-contamination of blood tubes additives, inappropriate sample storage conditions or repeated freezing-thawing cycles. Therefore, this article is aimed to summarize the current evidence about the most frequent types of unsuitable blood samples, along with tentative recommendations on how to prevent or manage these preanalytical non-conformities.<\/jats:p>","DOI":"10.1515\/dx-2018-0018","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T18:16:16Z","timestamp":1527704176000},"page":"25-31","source":"Crossref","is-referenced-by-count":122,"title":["Blood sample quality"],"prefix":"10.1515","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9054","authenticated-orcid":false,"given":"Giuseppe","family":"Lippi","sequence":"first","affiliation":[{"name":"Section of Clinical Biochemistry , University Hospital of Verona, Piazzale LA Scuro , 37100 \u2013 Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"von Meyer","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Medicine, Kliniken Nordoberpfalz AG and Klinikum St. Marien , Weiden and Amberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Cadamuro","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Paracelsus Medical University , Salzburg , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Simundic","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostics , University Hospital Sveti Duh , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"2025121207021145120_j_dx-2018-0018_ref_001_w2aab3b7b1b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Plebani M, Lippi G. 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