{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:30:53Z","timestamp":1765528253635,"version":"3.48.0"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We describe the case of Jessica Barnett, an adolescent girl whose repeated episodes of syncope and near-syncope were ascribed to a seizure or anxiety disorder. The correct diagnoses (congenital long QT syndrome; arrythmogenic right ventricular cardiomyopathy) were established by autopsy and genetic studies only after her death at age 17. The perspective of the family is presented, along with an analysis of what went right and what went wrong in Jessica\u2019s diagnostic journey. Key lessons in this case include the value of family as engaged members of the diagnostic team, that a \u2018hyperventilation test\u2019 should not be used to exclude cardiac origins of syncope or pre-syncope, and the inherent challenges in the diagnosis of the long QT syndrome.<\/jats:p>","DOI":"10.1515\/dx-2020-0113","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:58:50Z","timestamp":1611363530000},"page":"392-397","source":"Crossref","is-referenced-by-count":0,"title":["Learning from tragedy \u2013 The Jessica Barnett story: challenges in the diagnosis of long QT syndrome"],"prefix":"10.1515","volume":"8","author":[{"given":"Mark L.","family":"Graber","sequence":"first","affiliation":[{"name":"Society to Improve Diagnosis in Medicine , Plymouth , MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P. J.","family":"Olson","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics , University of Minnesota Medical School , Minneapolis , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Barnett","sequence":"additional","affiliation":[{"name":"Wolfville , NS , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025121207251124979_j_dx-2020-0113_ref_001","unstructured":"Do No Harm; Jess\u2019 story. Available from: https:\/\/www.youtube.com\/watch?v=t6mr3gxXx64&feature=youtu.be."},{"key":"2025121207251124979_j_dx-2020-0113_ref_002","doi-asserted-by":"crossref","unstructured":"Newman-Toker, D. A unified conceptual model for diagnostic errors: underdiagnosis, overdiagnosis, and misdiagnosis. 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Long-QT syndrome: misdiagnosis and overdiagnosis, clinical suspicion and the appropriate management. Paediatr Today 2012;8:5\u201310."},{"key":"2025121207251124979_j_dx-2020-0113_ref_007","doi-asserted-by":"crossref","unstructured":"Vetter, V. Clues or miscues? How to make the right interpretation and correctly diagnosis long-QT syndrome. Circulation 2007;115:2595\u20138.","DOI":"10.1161\/CIRCULATIONAHA.107.700195"},{"key":"2025121207251124979_j_dx-2020-0113_ref_008","doi-asserted-by":"crossref","unstructured":"Ramos-Maqueda, J, Bermudez-Jimenez, F, Ruiz, R, Ramos, M, Lerma, M, Millan, P, et al.. Prognostic impact of misdiagnosis of cardiac channelopathies as epilepsy. PloS One 2020;15:e0231442.","DOI":"10.1371\/journal.pone.0231442"},{"key":"2025121207251124979_j_dx-2020-0113_ref_009","doi-asserted-by":"crossref","unstructured":"MacCormick, J, McAllister, H, Crawford, J, French, J, Crozier, I, Shelling, A, et al.. Misdiagnosis of long QT syndrome as epilepsy at first presentation. Ann Emerg Med 2009;54:26\u201332.","DOI":"10.1016\/j.annemergmed.2009.01.031"},{"key":"2025121207251124979_j_dx-2020-0113_ref_010","doi-asserted-by":"crossref","unstructured":"Taggart, N, Haglund, C, Tester, D, Ackerman, M. Diagnostic miscues in congenital long-QT syndrome. Circulation 2007;115:2613\u201320.","DOI":"10.1161\/CIRCULATIONAHA.106.661082"},{"key":"2025121207251124979_j_dx-2020-0113_ref_011","unstructured":"Klein, G. Intuitive decisions: what physicians can learn from firefighters. In: Diagnostic error in medicine annual conference. Society to Improve Diagnosis in Medicine, Chicago, IL; 2011."},{"key":"2025121207251124979_j_dx-2020-0113_ref_012","doi-asserted-by":"crossref","unstructured":"McDonald, K, Bryce, C, Graber, M. The Patient is in: patient involvement strategies for diagnostic error mitigation. 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