{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:08:28Z","timestamp":1765523308516,"version":"3.48.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dx-2022-0084_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) structure and host tropism have changed over time, and so has the involvement of throat structures. This infodemiological analysis is hence aimed at investigating the evolution of throat symptoms during the COVID-19 pandemic in the US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2022-0084_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Google Trends using the medical search terms \u201cageusia\u201d, \u201choarseness\u201d, \u201cdysphonia\u201d, \u201cpharyngitis\u201d and \u201claryngitis\u201d, setting geographical location to \u201cUnited States\u201d, within the past 5\u00a0years. The weekly Google Trends score for these symptoms, which reflects their national Web popularity, was divided in three parts, as \u201cpre-COVID\u201d (July 2017 to February 2020), COVID-19 \u201cpre-Omicron\u201d (March 2020 to November 2021), and COVID-19 \u201cOmicron\u201d (December 2021 to July 2022), and then compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2022-0084_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The volume of searches for ageusia increased in\u00a0the pre-Omicron period and remained significantly higher also during Omicron prevalence, though a significant decrease (\u223c30%) occurred with Omicron lineages compared to previous strains. The Google searches for hoarseness and dysphonia were relatively similar between the pre-COVID and pre-Omicron periods, but then significantly increased during Omicron predominance. The Google searches for pharyngitis and laryngitis decreased in the pre-Omicron period, but then considerably increased following Omicron emergence. Omicron endemic spread could be significantly and independently predicted by the volume of searches for pharyngitis, laryngitis and hoarseness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2022-0084_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The epidemiological burden of throat symptoms has considerably changed after Omicron emergence, with a lower likelihood of developing chemosensory dysfunctions and enhanced risk of throat involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dx-2022-0084","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T10:48:46Z","timestamp":1660733326000},"page":"485-490","source":"Crossref","is-referenced-by-count":6,"title":["Evolution of throat symptoms during the COVID-19 pandemic in the US"],"prefix":"10.1515","volume":"9","author":[{"given":"Riccardo","family":"Nocini","sequence":"first","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics and Gynaecology-Unit of Otorhinolaryngology , University of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon M.","family":"Henry","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Division of Nephrology and Hypertension , Cincinnati Children\u2019s Hospital Medical Center , Cincinnati , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Mattiuzzi","sequence":"additional","affiliation":[{"name":"Service of Clinical Governance, Provincial Agency for Social and Sanitary Services (APSS) , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9054","authenticated-orcid":false,"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry and School of Medicine , University of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2025121206451502916_j_dx-2022-0084_ref_001","doi-asserted-by":"crossref","unstructured":"Lippi, G, Plebani, M. 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Nature 2022;601:177.","DOI":"10.1038\/d41586-022-00007-8"}],"container-title":["Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/dx-2022-0084\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/dx-2022-0084\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:04:18Z","timestamp":1765523058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/dx-2022-0084\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,9,26]]},"published-print":{"date-parts":[[2022,11,14]]}},"alternative-id":["10.1515\/dx-2022-0084"],"URL":"https:\/\/doi.org\/10.1515\/dx-2022-0084","relation":{},"ISSN":["2194-8011","2194-802X"],"issn-type":[{"type":"print","value":"2194-8011"},{"type":"electronic","value":"2194-802X"}],"subject":[],"published":{"date-parts":[[2022,8,18]]}}}