{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:12:01Z","timestamp":1765523521379,"version":"3.48.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dx-2024-0092_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This paper aims to identify and address gaps in cancer treatment and diagnosis within European health services, focusing specifically on discrepancies between clinical guidelines and policy guidelines. It seeks to highlight how the underutilization of advanced diagnostic techniques recommended by medical societies contributes to missed opportunities for improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0092_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive analysis was conducted across multiple European countries to assess the compliance and integration of clinical guidelines with the availability of advanced diagnostic technologies. Secondary data related to clinical and policy guidelines in cancer care were collected and analyzed. Key indicators of adoption and utilization of next-generation sequencing and liquid biopsy were examined to evaluate their impact on health service efficiency and patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0092_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis revealed significant discrepancies between the recommendations of medical societies regarding advanced diagnostic techniques and their adoption in health policy decisions across Europe. Country-specific assessments indicated varying levels of alignment between clinical guidelines and the availability of advanced diagnostics. These findings underscored missed opportunities for optimizing patient care and health service efficiency through better alignment and integration of clinical guidelines with policy decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0092_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study concludes that there is a critical need for health policy decision-makers to prioritize the adoption of clinical guidelines in resource allocation and health service organization. Greater attention to the recommendations of medical societies regarding advanced diagnostic techniques could significantly enhance diagnostic accuracy, treatment efficacy, and overall patient outcomes in cancer care. The paper advocates for policy reforms that acknowledge and leverage the potential benefits of advanced diagnostics in improving health service performance and patient-centered care across Europe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dx-2024-0092","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T04:11:40Z","timestamp":1722399100000},"page":"94-107","source":"Crossref","is-referenced-by-count":2,"title":["Bridging the divide: addressing discrepancies between clinical guidelines, policy guidelines, and biomarker utilization"],"prefix":"10.1515","volume":"12","author":[{"given":"Denis","family":"Horgan","sequence":"first","affiliation":[{"name":"European Alliance for Personalised Medicine , Brussels , Belgium"},{"name":"Department of Molecular and Cellular Engineering, Faculty of Engineering and Technology , Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences , Prayagraj , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[{"name":"European Liquid Biopsy Society , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Buttner","sequence":"additional","affiliation":[{"name":"Lung Cancer Group Cologne , Institute of Pathology and Medical Faculty, Center for Integrated Oncology Co-logne\/Bonn, University Hospital Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Rie\u00df","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Applied Genomics , University of Tuebingen , Tuebingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Lugowska","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma , Maria Sklodowska-Curie National Research Institute and Oncology Centre (MSCI) , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"France","family":"Dube","sequence":"additional","affiliation":[{"name":"Astra Zeneca, Concord Pike , Wilmington , DE , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Singh","sequence":"additional","affiliation":[{"name":"European Alliance for Personalised Medicine , Brussels , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Nadal","sequence":"additional","affiliation":[{"name":"Catalan Institute of Oncology, University of Barcelona , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Stok\u0142osa","sequence":"additional","affiliation":[{"name":"University Clinical Center, Medical University of Warsaw , Warsaw , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u012bna","family":"S\u012bvi\u0146a","sequence":"additional","affiliation":[{"name":"Tumour Clinical Research Department , Institute of Oncology, Riga Stradins University , Riga , Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Van der Buckle","sequence":"additional","affiliation":[{"name":"Belgian Cancer Centre , Sciensano , Brussels , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Mosoiu","sequence":"additional","affiliation":[{"name":"Oncology Department , University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bertolaccini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , IEO, European Institute of Oncology IRCCS , Milan , 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