{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:20:46Z","timestamp":1765524046534,"version":"3.48.0"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dx-2024-0176_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The measurement of fasting glucose is a common practice for lowering the risk of hyperglycemia before an oral glucose tolerance test (OGTT). In this study we analyze advantages and limitations of near-patient measurement of capillary fasting glucose with a portable glucometer or blood sampling and measurement of plasma glucose with laboratory instrumentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0176_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The final study population consisted of 241 subjects (mean age: 36\u00a0\u00b1\u00a08 years; 97.9\u202f% pregnant women) referred to our local phlebotomy center for an OGTT. Fasting glucose was measured in capillary blood using a near-patient glucometer (glucometer-based strategy) and in plasma with laboratory instrumentation using the hexokinase reference assay (laboratory-based strategy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0176_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean turnaround time from sample collection to obtaining the glucose value was longer with the laboratory-based strategy (32\u202fmin 8 vs. 8\u202fs). The imprecision of the glucometer was higher than that of the laboratory assay (3.4 vs. 0.8\u202f%). A negative bias of\u00a0\u22123.3\u202f% in fasting glucose was found with the glucometer compared to the laboratory measurement. The diagnostic accuracy, sensitivity and specificity of the glucometer for detecting fasting glucose values\u00a0\u22657.0\u202fmmol\/L were 99.2\u202f, 50.0 and 100.0\u202f% compared to the laboratory assay. The glucometer-based strategy had an incremental cost of 0.17\u20ac per patient compared to the laboratory-based strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2024-0176_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Screening fasting glucose in capillary blood with a near-patient glucometer instead of measuring fasting plasma glucose with laboratory instrumentation allows faster patient management in the phlebotomy center but is associated with higher imprecision, inaccuracy, costs and avoidable finger pricks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dx-2024-0176","type":"journal-article","created":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T23:00:47Z","timestamp":1733698847000},"page":"262-267","source":"Crossref","is-referenced-by-count":1,"title":["Screening fasting glucose before the OGTT: near-patient glucometer- or laboratory-based measurement?"],"prefix":"10.1515","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9054","authenticated-orcid":false,"given":"Giuseppe","family":"Lippi","sequence":"first","affiliation":[{"name":"Section of Clinical Biochemistry , University of Verona , Verona , Italy"},{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Visconti","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Martini","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-3764","authenticated-orcid":false,"given":"Davide","family":"Demonte","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lo Cascio","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Capizzi","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine , University Hospital of Verona , Verona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2025121206502940826_j_dx-2024-0176_ref_001","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee. 2. Diagnosis and classification of diabetes: standards of care in diabetes-2024. Diabetes Care 2024;47:S20-42. https:\/\/doi.org\/10.2337\/dc24-s002.","DOI":"10.2337\/dc24-S002"},{"key":"2025121206502940826_j_dx-2024-0176_ref_002","unstructured":"Carta, M, Mosca, A, Lapolla, A, Testa, R. 2015 recommendations for oral glucose tolerance testing (OGTT). Biochm Clin 2015;39:135\u201340."},{"key":"2025121206502940826_j_dx-2024-0176_ref_003","doi-asserted-by":"crossref","unstructured":"Mosca, A, Paleari, R, Montagnana, M. Aggiornate le linee guida dell\u2019American association of clinical chemistry sul ruolo del laboratorio Analisi nella diagnosi e nel monitoraggio del diabete mellito. Biochim Clin 2024;48:180\u20134.","DOI":"10.23736\/S1825-859X.24.00259-7"},{"key":"2025121206502940826_j_dx-2024-0176_ref_004","doi-asserted-by":"crossref","unstructured":"Tuomilehto, J. Point: a glucose tolerance test is important for clinical practice. 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Diabetes Care 2024;47:S295-306. https:\/\/doi.org\/10.2337\/dc24-s016.","DOI":"10.2337\/dc24-S016"},{"key":"2025121206502940826_j_dx-2024-0176_ref_012","doi-asserted-by":"crossref","unstructured":"Colagiuri, S, Sandbaek, A, Carstensen, B, Christensen, J, Glumer, C, Lauritzen, T, et al.. Comparability of venous and capillary glucose measurements in blood. Diabet Med 2003;20:953\u20136. https:\/\/doi.org\/10.1046\/j.1464-5491.2003.01048.x.","DOI":"10.1046\/j.1464-5491.2003.01048.x"},{"key":"2025121206502940826_j_dx-2024-0176_ref_013","doi-asserted-by":"crossref","unstructured":"Stauffer, F, Viswanathan, B, Jean, M, Kinabo, P, Bovet, P. Comparison between capillary glucose measured with a contour glucometer and plasma glucose in a population survey. 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