{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:17:34Z","timestamp":1788358654383,"version":"build-2803163510"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dx-2025-0055_abs_001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neurodegenerative diseases such as multiple sclerosis (MS), Alzheimer\u2019s disease (AD), and Parkinson\u2019s disease (PD) share overlapping clinical and pathological features, complicating early diagnosis and management. Demyelination, a key pathological hallmark, underscores the importance of accurately assessing white matter (WM) integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2025-0055_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>Myelin water imaging (MWI), an advanced non-invasive MRI technique, quantifies the myelin water fraction (MWF) and offers high specificity for detecting myelin abnormalities. This systematic review explores the feasibility and diagnostic utility of MWI across MS, AD, and PD by analyzing 21 high-quality studies from major databases, following PRISMA guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2025-0055_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>MWI consistently revealed reduced MWF in MS patients across various WM regions, lesion types, and disease stages, including responsiveness to early treatment. In AD, MWF decline correlated with disease progression and apolipoprotein E4 (APOE4) genotype, supporting its potential in early diagnosis. Findings in PD were inconsistent, reflecting secondary or minimal myelin involvement in its pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2025-0055_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>MWI shows strong promise as a non-invasive imaging biomarker, particularly in MS and AD. Standardization of acquisition protocols, integration with multimodal imaging, and further longitudinal studies are essential to establish its clinical utility and support broader implementation in neurodegenerative disease diagnostics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dx-2025-0055","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:58:26Z","timestamp":1751072306000},"page":"9-19","source":"Crossref","is-referenced-by-count":2,"title":["Myelin water imaging as a quantitative diagnostic tool for neurodegenerative diseases: a systematic review"],"prefix":"10.1515","volume":"13","author":[{"given":"Aswathi","family":"Puliyakkara","sequence":"first","affiliation":[{"name":"Medical Radiology and Diagnostic Imaging, School of Allied Health Sciences , REVA University , Bangalore , Karnataka , India"},{"name":"Department of Medical Imaging Technology , Institute of Allied Health Sciences, Srinivas University , Mangalore , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijith","family":"Shirlal","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology, Manipal College of Health Professions , Manipal Academy of Higher Education , Manipal , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikiran","family":"Pendem","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology, Manipal College of Health Professions , Manipal Academy of Higher Education , Manipal , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Priyanka","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology, Manipal College of Health Professions , Manipal Academy of Higher Education , Manipal , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Kadavigere","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Kasturba Medical College , Manipal Academy of Higher Education , Manipal , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thejas S.","family":"Marike","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology, Manipal College of Health Professions , Manipal Academy of Higher Education , Manipal , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"2026090213570838859_j_dx-2025-0055_ref_001","doi-asserted-by":"crossref","unstructured":"Syed, JM, Nemichandra, SC, Sridhar, SB, Shareef, J, Ramesh, M, Chalasani, SH. 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