{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:00:54Z","timestamp":1791997254013,"version":"4.4.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dx-2025-0104_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the impact of haematological and biochemical abnormalities on the failure of point-of-care troponin T (POCT) testing in patients with suspected acute coronary syndrome (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2025-0104_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>Five patients underwent Roche Troponin T Card Test (lateral flow immunoassay) in an emergency setting. Despite correct sampling and procedural adherence, no valid results were obtained resulting in an aborted test. Laboratory analysis revealed severe anaemia, polycythaemia, leucocytosis, thrombocytopenia, and hepatic and renal dysfunction across cases. After stabilization, repeat POCT yielded valid results in all survivors, correlating with normalized haematological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dx-2025-0104_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-analytical factors such as extreme haematocrit, leucocytosis, and biochemical derangements can cause POCT failure. Pre-testing screening and guideline updates are essential to optimize POCT reliability in acute\u00a0care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dx-2025-0104","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:58:05Z","timestamp":1756731485000},"page":"520-523","source":"Crossref","is-referenced-by-count":0,"title":["Pre-analytical interference in point-of-care troponin T testing: a case series"],"prefix":"10.1515","volume":"13","author":[{"given":"Lekha Priyadharshini","family":"Kamarajan","sequence":"first","affiliation":[{"name":"Department of Biochemistry , All India Institute of Medical Science Patna , Patna , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanshu","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , All India Institute of Medical Science Patna , Patna , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , All India Institute of Medical Science Patna , Patna , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Bhambhani","sequence":"additional","affiliation":[{"name":"Department of Cardiology , All India Institute of Medical Science Patna , Patna , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-6972","authenticated-orcid":false,"given":"Mala","family":"Mahto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , All India Institute of Medical Science Patna , Patna , Bihar , 801507 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"2026083110583446140_j_dx-2025-0104_ref_001","unstructured":"Cemin, R, Daves, M. Pre-analytic variability in cardiovascular biomarker testing: the dark side of the moon. Eur Heart J Suppl 2015;17:A2\u20135."},{"key":"2026083110583446140_j_dx-2025-0104_ref_002","unstructured":"von Lode, P, Laurila, P, Pulkki, K, Vuorinen, K, Astedt, B. Point-of-care testing of cardiac markers. Scand J Clin Lab Invest Suppl 2005;240:27\u201335."},{"key":"2026083110583446140_j_dx-2025-0104_ref_003","unstructured":"Lippi, G, Cervellin, G, Plebani, M. Preanalytical variability in troponin testing: implications for clinical practice. Clin Biochem 2011;44:1289\u201394."},{"key":"2026083110583446140_j_dx-2025-0104_ref_004","doi-asserted-by":"crossref","unstructured":"Okyay, GU, Y\u0131ld\u0131r\u0131r, A. Preanalytical and analytical factors responsible for false-positive cardiac troponins. 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Ann Clin Biochem 2010;47:101\u201310. https:\/\/doi.org\/10.1258\/acb.2009.009222.","DOI":"10.1258\/acb.2009.009222"},{"key":"2026083110583446140_j_dx-2025-0104_ref_008","unstructured":"Storrow, AB, Nowak, RM, Diercks, DB, Mihalik, G, Han, JH, McNaughton, CD, et al.. Absolute values of cardiac troponin predict adverse events in patients with chest pain and a non-diagnostic electrocardiogram: results from the EMCREG-international i*trACS study. Am J Emerg Med 2008;26:752\u20136."},{"key":"2026083110583446140_j_dx-2025-0104_ref_009","unstructured":"Collinson, PO, Gaze, DC, Bainbridge, K, Fry, CH, Flather, M, Goodacre, S, et al.. Utility of cardiac troponin measurement in hospital patients with chest pain and suspected acute coronary syndrome. Heart 2006;92:378\u201380."},{"key":"2026083110583446140_j_dx-2025-0104_ref_010","doi-asserted-by":"crossref","unstructured":"Goodacre, S, Cross, E, Arnold, J, Angelini, K, Capewell, S, Nicholl, J. The health care burden of acute chest pain. 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