{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:53:21Z","timestamp":1777949601357,"version":"3.51.4"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n This study aimed to validate the analytical performance of high-sensitivity cardiac troponin I (hs-cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) assays, and to establish age- and sex-specific reference intervals (RIs) using a large multicenter Chinese cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n hs-cTnI and NT-proBNP were measured on a fully automated chemiluminescence platform (Maglumi X8, Snibe, China). Analytical performance was validated following Clinical and Laboratory Standards Institute guidelines. Sex- and age-specific RIs for hs-cTnI (n=2,323) and NT-proBNP (n=2,333) were determined nonparametrically from IFCC-compliant cohorts across six Chinese provinces.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Analytical validation confirmed high sensitivity, specificity, satisfactory linearity, and strong interference resistance of hs-cTnI and NT-proBNP. hs-cTnI demonstrated 3.19\u202f% total imprecision near 99th percentile URLs and >99.5\u202f% detectable rates (>LoD) in healthy individuals, meeting third-generation hs-cTn criteria. RIs were established stratified by age and sex. In plasma, RIs of hs-cTnI were 11.97\u202fng\/L for males and 11.61\u202fng\/L for females, while 97.5th percentile URLs of NT-proBNP were 145.00\u202fng\/L overall, 113.63\u202fng\/L for males, and 160.75\u202fng\/L for females. Elevated hs-cTnI levels were observed in residents of Ningxia and in women with central obesity.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The Snibe hs-cTnI assay fulfills IFCC high-sensitivity criteria. Age- and sex-specific RIs of hs-cTnI and NT-proBNP were established from a large multicenter Chinese cohort, confirming their essential role in accurate cardiovascular risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/dx-2026-0045","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:56:43Z","timestamp":1777863403000},"source":"Crossref","is-referenced-by-count":0,"title":["Multicenter reference limits of hs-cTnI and NT-proBNP in a Chinese cohort"],"prefix":"10.1515","author":[{"given":"Yuxin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine , Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories , Zhejiang Green Town Cardiovascular Hospital , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huabin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory , Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases , Xiamen , China"},{"name":"Department of Clinical Laboratory , Xiamen Key Laboratory of Precision Medicine for Cardiovascular Disease , Xiamen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Clinical Laboratories , The Affiliated Hospital of Guizhou Medical University , Guiyang , Guizhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poshi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory , Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University , Zhengzhou , Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Medical Science Affairs , Shenzhen New Industries Biomedical Engineering Co., Ltd. , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Examination , Shenzhen Cadre Talent Health Management Center , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , First Affiliated Hospital of Shenzhen University , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine , General Hospital of Ningxia Medical University , Ningxia , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"2026050402563516444_j_dx-2026-0045_ref_001","doi-asserted-by":"crossref","unstructured":"Liu, M, He, X, Yang, X, Wang, Z. 2024 annual report on cardiovascular health and diseases in China: data and trend. 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