{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:29Z","timestamp":1787237729934,"version":"build-2736575974"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto\u2019s thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance.<\/jats:p>\n                  <jats:p>Methods. One hundred-twenty eight subjects, newly diagnosed hypothyroid HT patients [56 overt (Group 1), 72 subclinical hypothyroid (Group 2)] and 38 healthy controls (Group 3) were enrolled in the study. The levels of serum IL-35 were determined by enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <jats:p>Results. Serum IL-35 levels were lower in the HT group when compared with subclinical HT group [304.5 (834.6) pg\/ml vs. 636.1 (1542.0) pg\/ml, p=0.004] and control cases [304.5 (834.6) pg\/ml vs. 1064.7 (2526.8) pg\/ml, p&lt;0.001]. Serum IL-35 levels were inversely associated with thyroid stimulating hormone (TSH; rs=-0.396, p&lt;0.001) and anti-thyroid peroxidase antibodies (TPOAb; rs=-0.571, p&lt;0.001) in whole group. Serum IL-35 were negatively associated with TSH (rs=-0.264, p=0.003) and TPOAb (rs=-0.735, p&lt;0.001) in patients with Hashimoto\u2019s thyroiditis (Group 1 + Group 2).<\/jats:p>\n                  <jats:p>Conclusion. The results suggest that IL-35 may play a role in the pathogenesis of HT.<\/jats:p>","DOI":"10.1515\/enr-2016-0009","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T06:10:52Z","timestamp":1463551852000},"page":"55-61","source":"Crossref","is-referenced-by-count":12,"title":["Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto\u2019s thyroiditis"],"prefix":"10.1515","volume":"50","author":[{"given":"Hakki","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dr. A. Y. Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Turgut Ozal University, School of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ceydilek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Turgut Ozal University, School of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr. A. Y. Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr. A. Y. Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,5,18]]},"container-title":["Endocrine Regulations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/enr\/50\/2\/article-p55.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/enr-2016-0009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T16:14:02Z","timestamp":1617898442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/enr-2016-0009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,5,18]]},"published-print":{"date-parts":[[2016,4,1]]}},"alternative-id":["10.1515\/enr-2016-0009"],"URL":"https:\/\/doi.org\/10.1515\/enr-2016-0009","relation":{},"ISSN":["1336-0329"],"issn-type":[{"value":"1336-0329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,1]]}}}