{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:41:48Z","timestamp":1781538108202,"version":"3.54.5"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tenomodulin is a type II transmembrane glycoprotein that can regulate growth of tendon. The human tenomodulin encoding gene is mapped to \u0425 chromosome and encodes a polypeptide consisting of 317 alpha amino acids. The protein is located on the cell surface as N-glycosylated or non-N-glycosylated polypeptide with molecular mass of 45 and 40 kDa, respectively. The molecule consists of three domains and a short cytoplasmic tail at N-terminus. Tenomodulin is predominantly expressed in dense connective hypovascularized tissues such as tendons, skeletal muscle epimysium, and ligaments. Furthermore, tenomodulin is an efficient marker of tenocyte differentiation and plays an important role in the regulation of tenocyte proliferation, tendon development, and angiogenesis inhibition. A number of tenomodulin gene polymorphisms have been recently associated with a risk of obesity, diabetes, systemic immune mediators, cholesterol levels, Alzheimer disease, and age-related macular degeneration. Tenomodulin is involved in cell adhesion, determination of cell morphology, cell aging and bone mineral density. It is expected to play an important role in tendon recovery, tendon tissue engineering, anti-tumor therapy, treatment of chordal disruption, and remodeling of extracellular matrix.<\/jats:p>","DOI":"10.1515\/folmed-2016-0003","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T10:03:39Z","timestamp":1467799419000},"page":"19-27","source":"Crossref","is-referenced-by-count":11,"title":["A Prospectus of Tenomodulin"],"prefix":"10.1515","volume":"58","author":[{"given":"Vesselin P.","family":"Alexandrov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir I.","family":"Naimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref71","first-page":"333","article-title":"and tenomodulin : a new class of tissue - specific angiogenesis inhibitors found in hypovascular connective tissues","author":"Shukunami","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12265-011-9317-8","article-title":"Role of angiogenetic factors in cardiac valve homeostasis and disease","volume":"4","author":"Hakuno","year":"2011","journal-title":"J Cardiovasc Transl Res"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1152\/japplphysiol.00198.2012","article-title":"Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin","volume":"113","author":"Qi","year":"2012","journal-title":"J Appl Physiol"},{"key":"ref181","first-page":"298","article-title":"Scleraxis positively regulates the expression of tenomodulin , a differentiation marker of tenocytes","author":"Shukunami","year":"2006","journal-title":"Dev Biol"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1294\/jes.25.7","article-title":"Regulation of Tenomodulin Expression Via Wnt \/ \u03b2 - catenin Signaling in Equine Bone Marrow - derived Mesenchymal Stem Cells","volume":"25","author":"Miyabara","year":"2014","journal-title":"J Equine Sci"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/07853891003801123","article-title":"Tenomodulin gene and obesity - related phenotypes","volume":"42","author":"Tolppanen","year":"2010","journal-title":"Ann Med"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.7150\/ijms.6774","article-title":"Recombinant human adiponectin as a potential protein for treating diabetic tendinopathy promotes tenocyte progenitor cells proliferation and tenogenic differentiation in vitro","volume":"10","author":"Rothan","year":"2013","journal-title":"Int J Med Sci"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/scd.2014.0314","article-title":"Loss of tenomodulin results in reduced self - renewal and augmented senescence of tendon stem \/ progenitor cells","volume":"24","author":"Alberton","year":"2015","journal-title":"Stem Cells Dev"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"60203","DOI":"10.1371\/journal.pone.0060203","article-title":"Tenomodulin expression in the periodontal ligament enhances cellular adhesion","volume":"8","author":"Komiyama","year":"2013","journal-title":"PLoS One"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jor.20999","article-title":"Tendonselective genes identified from rat and human musculoskeletal tissues","volume":"28","author":"Jelinsky","year":"2010","journal-title":"J Orthop Res"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"15373","DOI":"10.3390\/ijms131115373","article-title":"Tenomodulin inhibits retinal neovascularization in a mouse model of oxygen - induced retinopathy","volume":"13","author":"Wang","year":"2012","journal-title":"Int J Mol Sci"},{"key":"ref161","first-page":"94","article-title":"Tenomodulin Is Highly Expressed in Adipose Tissue , Increased in Obesity , and Down - Regulated during Diet - Induced Weight Loss","author":"Saiki","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref251","first-page":"481","article-title":"The roles of calcium and phosphorus in cardiovascular diseases The role of angiogenetic factors in the pathogenesis and the progression of cardiac valve disease","volume":"23","author":"Kusumoto","year":"2013","journal-title":"Clin Calcium"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0968-0004(02)02134-5","article-title":"BRICHOS : a conserved domain in proteins associated with dementia , respiratory distress and cancer","volume":"27","author":"Sanchez","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"ref141","first-page":"175","article-title":"Molecular cloning of a new class of cartilage - 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deficient mice are small brittle and hypocellular","volume":"105","author":"Mendias","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/MCB.25.2.699-705.2005","article-title":"Tenomodulin is necessary for tenocyte proliferation and tendon maturation","volume":"25","author":"Docheva","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref61","first-page":"117","article-title":"Anti - angiogenic action of the C - terminal domain of tenomodulin that shares homology with chondromodulin - I","author":"Oshima","year":"2004","journal-title":"J Cell Sci"},{"key":"ref41","first-page":"44","article-title":"Expression and localization of tenomodulin , a transmembrane type chondromodulin - I - related angiogenesis inhibitor , in mouse eyes","author":"Oshima","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/dvdy.1126","article-title":"A novel gene tendin is strongly expressed in tendons and ligaments and shows high homology with Chondromodulin - 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