{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:12:33Z","timestamp":1776327153262,"version":"3.50.1"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients. Cognitive dysfunctions impact significantly patients\u2019 quality of life, independently from the course and phase of the disease.<\/jats:p>\n<jats:p>The relationship between pathological brain findings and cognitive impairment is a subject of intensive research.<\/jats:p>\n<jats:p>Summarizing recent data about prevalence, clinical specificity and treatment of cognitive disorders in MS, this review aims to motivate the necessity of early diagnosis and complex therapeutic approach to these disturbances in order to reduce the social burden of the disease.<\/jats:p>","DOI":"10.1515\/folmed-2016-0029","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T10:02:12Z","timestamp":1476871332000},"page":"157-163","source":"Crossref","is-referenced-by-count":36,"title":["Cognitive Impairment in Multiple Sclerosis"],"prefix":"10.1515","volume":"58","author":[{"given":"Anastasiya G.","family":"Trenova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgi S.","family":"Slavov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Manova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana B.","family":"Aksentieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyuba D.","family":"Miteva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spaska A.","family":"Stanilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/S1355617707070580","article-title":"Information processing deficits in multiple sclerosis : a matter of complexity","volume":"13","author":"Parmenter","year":"2007","journal-title":"J Int Neuropsychol Soc"},{"key":"ref461","first-page":"10017","article-title":"National Clinical Advisory Board of the National Multiple Sclerosis Society Treatment Recommendations for Physicians : Assessment and Management of Cognitive Impairment in Multiple Sclerosis Expert Opinion New York","author":"Benedict","year":"2008","journal-title":"Paper"},{"key":"ref221","article-title":"Relevance of brain lesion location to cognition in relapsing multiple sclerosis","volume":"7","author":"Rossi","year":"2012","journal-title":"PLoS ONE"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.msard.2013.04.004","article-title":"Vision and multiple sclerosis","volume":"3","author":"Hickman","year":"2014","journal-title":"Mult Scler Rel Dis"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1017\/S1355617710000688","article-title":"Cognitive reserve moderates decline in information processing speed in multiple sclerosis patients","volume":"16","author":"Benedict","year":"2010","journal-title":"J Int Neuropsychol Soc"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.acn.2007.09.005","article-title":"Executive dysfunction and cognitive impairment in a large community - 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