{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:04Z","timestamp":1792686244818,"version":"4.5.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p> Background: A low Apgar score at 5 minutes has been shown to be a risk factor for development of retinopathy of prematurity (ROP).<\/jats:p>\n\t\t\t\t<jats:p>Aim: To examine the prognostic value of Apgar score at 5 minutes for development and progression of ROP.<\/jats:p>\n\t\t\t\t<jats:p>Materials and methods: The study included 132 preterm infants who were screened from 4th week of life onward. Of these, 118 newborns were given Apgar score at 5 minutes. The prognostic significance of this index was studied as an absolute value and as a value \u2264 6. The patients were divided into two groups: group I had no evidence of ROP (n=82) and group II had some signs of ROP (n = 36). Group II was further divided into group IIA - spontaneously regressed cases (n=22), and group IIB with cases which progressed to treatment stages (n=14). We investigated 15 maternal and 20 newborn presumable risk factors for development and progression of ROP. Mann-Whitney U test, \u03c7<jats:sup>2<\/jats:sup> or Fisher\u2019s exact test were used in the statistical analysis. Logistic regression was performed to find significant and independent risk factors for manifestation and progression of ROP.<\/jats:p>\n\t\t\t\t<jats:p>Results: A low 5-minute Apgar score and an Apgar score of 6 or less at 5 minutes were not statistically significant risk factors of ROP (\u0440=0.191, \u0440=0.191, respectively), but were significant risk factors for the manifested ROP to progress to stages requiring treatment (p=0.046, \u0440=0.036, respectively).<\/jats:p>\n\t\t\t\t<jats:p>Conclusion: An Apgar score at 5 minutes of 6 or less was a significant and independent risk factor for progression of ROP to stages requiring treatment.<\/jats:p>","DOI":"10.1515\/folmed-2017-0011","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T10:03:35Z","timestamp":1491473015000},"page":"78-83","source":"Crossref","is-referenced-by-count":14,"title":["The 5-minute Apgar Score as a Prognostic Factor for Development and Progression of Retinopathy of Prematurity"],"prefix":"10.1515","volume":"59","author":[{"given":"Vasil G.","family":"Marinov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desislava N.","family":"Koleva-Georgieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly P.","family":"Sivkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya B.","family":"Krasteva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref121","first-page":"223","article-title":"Score for neonatal acute physiology and perinatal extension II as a predictor for retinopathy of prematurity : study in very - 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