{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:41:54Z","timestamp":1782146514660,"version":"3.54.5"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold>There is no specific toxicological screening of clinical laboratory parameters in clinical toxicology when it comes to acute exogenous poisoning.<\/jats:p><jats:p><jats:bold>Aim:<\/jats:bold>To determine routine clinical laboratory parameters and indicators for assessment of vital functions in patients with acute intoxications.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold>One hundred and fifty-three patients were included in the present study. They were hospitalized in the Department of Clinical Toxicology at St. George University Hospital, Plovdiv for cerebral toxicity inducing medication (n = 45), alcohol (n = 40), heroin abuse (n = 33). The controls were 35. The laboratory tests were conducted in compliance with the standards of the clinical laboratory. We used the following statistical analyses: analysis of variance (the ucriterion of normal distribution, the Student\u2019s t-test, dispersion analysis based on ANOVA) and non-parametric analysis.<\/jats:p><jats:p><jats:bold>Results and discussion:<\/jats:bold>Based on the routine hematological parameters with statistically significant changes in three groups of poisoning are: red blood cells, hematocrit, hemoglobin (except alcohol intoxication) and leukocytes. We found statistically significant changes in serum total protein, sodium and bilirubin. The highest statistical significance is the increased activity of AST and ALT.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>We present a model for selection of clinical laboratory tests for severe acute poisoning with modern equipment under standardized conditions. The results of the study suggest that the clinical laboratory constellation we used can be used as a mandatory element in the diagnosis of moderate and severe intoxication with the mentioned toxic substances.<\/jats:p>","DOI":"10.1515\/folmed-2017-0058","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:05:58Z","timestamp":1507111558000},"page":"303-309","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Laboratory Tests in Some Acute Exogenous Poisonings"],"prefix":"10.1515","volume":"59","author":[{"given":"Stoilka G.","family":"Tufkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan V.","family":"Yankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana A.","family":"Paskaleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref161","first-page":"519","article-title":"ID DJ of abuse management of intoxication and antidotes","volume":"17","author":"Montoya","year":"2010","journal-title":"Drug EXS"},{"key":"ref121","article-title":"Place des examens compl\u00e9mentaires dans la d\u00e9marche th\u00e9rapeutique de l urgence toxicologique","volume":"13","author":"Taboulet","year":"1994","journal-title":"Med"},{"key":"ref141","first-page":"152","article-title":"Kraut Simple diagnostic tests to detect toxic alcohol intoxications","volume":"15","author":"Shin","year":"2008","journal-title":"Transl Res"},{"key":"ref21","article-title":"NA editors Emergencies th ed Connecticut","author":"Goldfrank","year":"1990"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/jat\/3.4.133","article-title":"Survey of emergency toxicology screening in a university medical center","author":"Bailey","year":"1979","journal-title":"J Anal Toxicol"},{"key":"ref201","article-title":"Can duration of hemodialysis be estimated based on the on - 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