{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:05:34Z","timestamp":1780499134295,"version":"3.54.1"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold>There is a high incidence of blood transfusion following hip fractures in elderly patients.<\/jats:p><jats:p><jats:bold>Aim:<\/jats:bold>The aim of this study is to evaluate the effectiveness and complications of use of tranexamic acid in proximal femur nailing surgery.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold>Our sample group consisted of 90 patients suffering from pertrochanteric fractures surgically treated with osteosynthesis with SupernailGT(LimaCorporate). The classification system AO\/OTA was used to divide the fractures into 31A1 (n=45) and 31A2 (n=45). The patients were divided into two groups: 47 patients were administered 15 mg of tranexamic acid per kg (group A) and 43 patients were administered placebo (group B). Blood counts were monitored daily to evaluate the rate of anemia. As a safety criterion, we monitored the possible occurrence of vascular events, symptomatic or not, over the 8 weeks post-surgery. Markers predicting mortality and deep venous thrombosis (DVE) were also monitored (fibrinogen D-dimer).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Blood loss occurring post-surgery can be influenced by numerous factors that are not linked to the use or non-use of tranexamic acid. While closely monitoring hemoglobin levels daily, we observed that 42% of the patients in group A required blood transfusion as opposed to 60% in group B. The results of the markers predicting mortality (alpha1-acid glycoprotein; albumin LDL) and those of DVE were not statistically significant between the two groups in this study (p&gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>Based on this study, the use of tranexamic acid was statistically significant in reducing post-surgery blood loss.<\/jats:p>","DOI":"10.1515\/folmed-2017-0070","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T22:16:03Z","timestamp":1524089763000},"page":"67-78","source":"Crossref","is-referenced-by-count":29,"title":["Tranexamic Acid in Pertrochanteric Femoral Fracture: Is it a Safe Drug or Not?"],"prefix":"10.1515","volume":"60","author":[{"given":"Andrea","family":"Schiavone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bisaccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Inkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rinonapoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Manni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Meccariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Ib\u00e1\u00f1ez","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ceccarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelinda","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auro","family":"Caraffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref431","first-page":"2015","article-title":"Current status of blood transfusion and antifibrinolytic therapy in orthopedic surgeries Front","author":"Stoicea"},{"key":"ref231","first-page":"349","article-title":"Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States : retrospective analysis of effectiveness and safety","volume":"24","author":"Poeran","year":"2014"},{"key":"ref331","first-page":"693","article-title":"Goldwasser Association of serum albumin and mortality risk","author":"Feldman","year":"1997","journal-title":"J Clin Epidemiol"},{"key":"ref81","first-page":"356","article-title":"Prevention and treatment of major blood loss","volume":"11","author":"Mannucci","year":"2007","journal-title":"Engl J Med"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/bcp.13079","article-title":"TO systematic review of tranexamic acid in hip fracture surgery","volume":"28","author":"Farrow","year":"2016","journal-title":"J Clin Pharmacol"},{"key":"ref41","first-page":"1","article-title":"Functional outcome after hip fracture year prospective outcome study of patients","author":"Rosell","year":"2003","journal-title":"Injury"},{"key":"ref151","first-page":"2015","article-title":"Prospective randomized controlled trial of two different intramedullary nails for pertrochanteric fractures of the femur","volume":"16","author":"Andreani","journal-title":"Technol Int"},{"key":"ref111","first-page":"186","article-title":"The use of tranexamic acid to reduce blood loss and transfusion in major orthopedic surgery meta analysis","volume":"12","author":"Huang","year":"2014","journal-title":"J Surg Res"},{"key":"ref61","first-page":"205","article-title":"Rising costs of hip fractures","author":"Loefler","year":"2016","journal-title":"Med"},{"key":"ref391","first-page":"137","article-title":"Application of tranexamic acid in trauma and orthopedic","volume":"47","author":"Jennings","year":"2016","journal-title":"surgery Clin Am"},{"key":"ref01","first-page":"9","article-title":"Clinical and radiological outcomes of distal radius fractures treated with orif with volar fixed - 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