{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:04:17Z","timestamp":1704729857058},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Background:<\/jats:bold> Abnormal secretion of TNF-\u03b1 is known to play a role in the pathogenesis of dermatomyositis and systemic lupus erythematosus.<\/jats:p>\n<jats:p><jats:bold>Materials and methods:<\/jats:bold> In the present study we have analyzed the concentrations of TNF-\u03b1 in the sera of 30 patients with systemic lupus erythematosus (SLE), 28 with dermatomyositis (DM) and 30 healthy controls by standard ELISA tests.<\/jats:p>\n<jats:p><jats:bold>Results:<\/jats:bold> We have found that -308A allele increases TNF-\u03b1 secretion, while -1031C and -863A alleles decrease it. The -857C\/T and 489G\/A polymorphisms appeared in strong linkage disequilibrium (D\u2019=0.93) but they did not seem to affect TNF-\u03b1 secretion.<\/jats:p>\n<jats:p><jats:bold>Conclusion:<\/jats:bold> TNF-\u03b1 polymorphisms play a significant role in its secretion and influence the development of DM and SLE.<\/jats:p>","DOI":"10.1515\/folmed-2017-0084","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:33:08Z","timestamp":1531960388000},"page":"216-220","source":"Crossref","is-referenced-by-count":4,"title":["Genetically Determined TNF-\u03b1 Secretion Influences the Development of Dermatomyositis and Systemic Lupus Erythematosus"],"prefix":"10.1515","volume":"60","author":[{"given":"Lyubomir A.","family":"Dourmishev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria H.","family":"Hristova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zornitsa G.","family":"Kamenarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey S.","family":"Savov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton I.","family":"Vinkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radka","family":"Kaneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanjo","family":"Mitev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/folmed\/60\/2\/article-p216.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T09:06:49Z","timestamp":1603271209000},"score":1,"resource":{"primary":{"URL":"http:\/\/archive.sciendo.com\/FOLMED\/folmed.2017.60.issue-2\/folmed-2017-0084\/folmed-2017-0084.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/folmed-2017-0084","relation":{},"ISSN":["1314-2143"],"issn-type":[{"value":"1314-2143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,1]]}}}