{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:00:18Z","timestamp":1791198018183,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The focus of this review is the lipodystrophy syndrome caused by mutation in the PPAR\u03b3 nuclear receptor \u2013 partial familial lipodystrophy FPLD3. To provide a broader context for how these mutations act to generate the clinical features of partial lipodystrophy we will review the basic biology of PPAR\u03b3 and also survey the set PPAR\u03b3 genetic variants that do not cause lipodystrophy, but are nonetheless associated with clinically related syndromes, specifically type 2 diabetes.<\/jats:p>","DOI":"10.1515\/hmbci-2014-0033","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T13:15:39Z","timestamp":1417526139000},"page":"63-70","source":"Crossref","is-referenced-by-count":9,"title":["PPAR\u03b3 mutations, lipodystrophy and diabetes"],"prefix":"10.1515","volume":"20","author":[{"given":"Olga","family":"Astapova","sequence":"first","affiliation":[{"name":"Center for Integrative Metabolic and Endocrine and Research, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Leff","sequence":"additional","affiliation":[{"name":"Center for Integrative Metabolic and Endocrine and Research, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,12,2]]},"container-title":["Hormone Molecular Biology and Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2014-0033\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2014-0033\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:57:14Z","timestamp":1765526234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2014-0033\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,11,21]]},"published-print":{"date-parts":[[2014,11,1]]}},"alternative-id":["10.1515\/hmbci-2014-0033"],"URL":"https:\/\/doi.org\/10.1515\/hmbci-2014-0033","relation":{},"ISSN":["1868-1891","1868-1883"],"issn-type":[{"value":"1868-1891","type":"electronic"},{"value":"1868-1883","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,1]]}}}