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Each of these conditions is also associated with an increase in pro-inflammatory cytokines. An inflammatory state characterized by an increase in pro-inflammatory markers including but not restricted to tumor necrosis factor-\u03b1, interleukin-6, IL-1\u03b2, and C-reactive protein (CRP) is believed to contribute to or worsen a general decline in biological mechanisms responsible for physical function with aging. Nutritional management of inflammation in aging dogs is important in maintaining health. In particular, natural botanicals have bioactive components that appear to have robust anti-inflammatory effects and, when included in the diet, may contribute to a reduction in inflammation. While there are scientific data to support the anti-inflammatory effects and the efficacy of such bioactive molecules from botanicals, the clinical data are limited and more studies are needed to validate the efficacy of these ingredients. This review will summarize the role of dietary ingredients in reducing inflammatory molecules as well as review the evidence available to support the role of diet and nutrition in reducing chronic low-grade systemic inflammation in animal and human studies with a special reference to canines, where possible.<\/jats:p>","DOI":"10.1515\/hmbci-2015-0017","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T03:51:43Z","timestamp":1435636303000},"page":"59-70","source":"Crossref","is-referenced-by-count":40,"title":["The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging"],"prefix":"10.1515","volume":"23","author":[{"given":"Kiran S.","family":"Panickar","sequence":"first","affiliation":[{"name":"Science and Technology Center, Hill\u2019s Pet Nutrition Center, PO Box 1658, 1035 NE 43rd St., Topeka, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Jewell","sequence":"additional","affiliation":[{"name":"Science and Technology Center, Hill\u2019s Pet Nutrition Center, PO Box 1658, 1035 NE 43rd St., Topeka, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,6,27]]},"reference":[{"key":"2025121207282831956_j_hmbci-2015-0017_ref_001_w2aab3b8b1b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Br\u00fc\u00fcnsgaard H, Pedersen BK. 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