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Here, we review on the effects of the two major adipokines (leptin and adiponectin) on fertility, with a focus on the first steps in embryo implantation and the key components of fetal-maternal interface (the placenta and the endometrium). These adipokines are reportedly involved in the regulation of cell proliferation and differentiation, and as such affect local angiogenesis, immune tolerance and inflammatory processes in placental and endometrial tissues. In placental cells, leptin and adiponectin also modulate trophoblast invasiveness and the nutrient supply. These observations strongly suggest by interfering with the placenta and endometrium, adipokines can create a favorable environment for embryo implantation and have a key role in fetal-maternal metabolism, fetal-maternal communication, and gestation. Given that reproductive functions are tightly coupled to the energy balance, metabolic abnormalities may lead to the development of complications of pregnancy and changes in fetal growth. In this context, we suggest that the leptin\/adiponectin ratio may be a clinically valuable marker for detecting a number of pathologies in pregnancy.<\/jats:p>","DOI":"10.1515\/hmbci-2015-0031","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T14:43:51Z","timestamp":1446043431000},"page":"47-63","source":"Crossref","is-referenced-by-count":45,"title":["The roles of leptin and adiponectin at the fetal-maternal interface in humans"],"prefix":"10.1515","volume":"24","author":[{"given":"Esther","family":"Dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Duval","sequence":"additional","affiliation":[{"name":"GIG-EA 2493, Universit\u00e9 de Versailles-St Quentin, UFR des Sciences de la Sant\u00e9, F-78180 Montigny le Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vialard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-No\u00eblle","family":"Dieudonn\u00e9","sequence":"additional","affiliation":[{"name":"GIG-EA 2493, Universit\u00e9 de Versailles-St Quentin, UFR des Sciences de la Sant\u00e9, F-78180 Montigny le Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"2025121207290336209_j_hmbci-2015-0031_ref_001_w2aab3b8b6b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Reverchon M, Ram\u00e9 C, Bertoldo M, Dupont J. 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