{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:57:05Z","timestamp":1765529825349,"version":"3.48.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Progestin supplementation appears to be a promising approach to both preventing initiation of pre-term labor and treating it once it is already established. Successful pregnancy depends on maternal tolerance of the fetal \u201csemi-allograft\u201d. A protein called progesterone-induced blocking factor (PIBF), by inducing a Th2 dominant cytokine production mediates the immunological effects of progesterone. Over time, various attempts have been made to clarify the question, whether progestogens can contribute positively to either prevention or treatment of pre-term labor and birth. Dydrogesterone treatment of women at risk of pre-term delivery results in increased PIBF production and IL-10 concentrations, and lower concentrations of IFN\u03b3 and could be effective for prevention or treatment of pre-term labor. Further randomized studies are needed.<\/jats:p>","DOI":"10.1515\/hmbci-2015-0064","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T05:01:21Z","timestamp":1474866081000},"page":"81-83","source":"Crossref","is-referenced-by-count":5,"title":["Dydrogesterone and pre-term birth"],"prefix":"10.1515","volume":"27","author":[{"given":"Igor","family":"Hudic","sequence":"first","affiliation":[{"name":"University Clinical Center Tuzla, Clinic for Obstetrics and Gynecology, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolf E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Institute for Medical Research and Education, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Szekeres-Bartho","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Pecs University, Medical School, Pecs, Hungary, Janos Szentagothai Research Centre, Pecs, Hungary, MTA-PTE Human Reproduction Scientific Research Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babill","family":"Stray-Pedersen","sequence":"additional","affiliation":[{"name":"Division of Women and Children, Rikshospitalet, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"2025121207311942316_j_hmbci-2015-0064_ref_001_w2aab3b8c10b1b7b1ab2b2b1Aa","unstructured":"Hamilton BE, Martin JA, Ventura SJ. 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