{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:37:55Z","timestamp":1768876675044,"version":"3.49.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_hmbci-2016-0024_s_999_w2aab3b8b2b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) is a heterogeneous disease characterised by an absolute or relative deficiency of insulin and insulin resistance. Diabetes is occurring at younger age in India. It is estimated that 20% of the type 2 DM patients reach end-stage renal disease (ESRD) during their lifetime. Recently, it has been proposed that hypomagnesaemia is a novel factor implicated in the pathogenesis of diabetic complications. Considering this, a study was designed to estimate the prevalence and association of hypomagnesaemia with diabetic nephropathy in North Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2016-0024_s_998_w2aab3b8b2b1b7b1aab1c15b2Aa\">\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>\n                      The investigated clinical group composed of 100 type 2 diabetics, grouped into two, on the basis of presence or absence of diabetic nephropathy with n=50 each. Biochemical investigations including fasting blood sugar (BS-F), blood urea, creatinine, magnesium (Mg), urinary albumin-creatinine ratio (U-A\/C ratio) were carried out. Descriptive statistics was applied to described frequency and means. \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      -Test and Student\u2019s t\n                      <jats:italic>-<\/jats:italic>\n                      tests were used to analyze associations between categorical and continuous variables, respectively. Pearson\u2019s correlation was done to find the association of nephropathy with hypomagnesaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2016-0024_s_997_w2aab3b8b2b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We observed that 37% of diabetic patients had hypomagnesaemia (mean=1.40\u00b10.16 mg\/dL). There was also a significantly higher prevalence of hypomagnesaemia (52%) in DM nephropathy patients (mean=1.62\u00b10.31 mg\/dL) compared to without nephropathy patients (22%, mean=1.86\u00b10.28 mg\/dL). Serum magnesium levels were significantly inversely correlated with serum creatinine (r=\u20130.222, p=0.026) and U-A\/C ratio (r=\u20130.352, p=0.000), and positively correlated with glomerular filtration rate (GFR) (r=0.304, p=0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2016-0024_s_996_w2aab3b8b2b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We concluded that hypomagnesaemia was significantly associated with higher prevalence of diabetic nephropathy and can be used as a marker for the risk of development of diabetic nephropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/hmbci-2016-0024","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T07:29:51Z","timestamp":1468481391000},"page":"79-84","source":"Crossref","is-referenced-by-count":17,"title":["Hypomagnesaemia: a modifiable risk factor of diabetic nephropathy"],"prefix":"10.1515","volume":"29","author":[{"given":"Sonny","family":"Bherwani","sequence":"first","affiliation":[{"name":"Department of Accident and Emergency Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srushtee Bipin","family":"Jibhkate","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Saumya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College (LHMC), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitendu Kumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Max Super Specialty Hospital, Saket, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Lady Hardinge Medical College (LHMC), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.H.","family":"Ghotekar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lady Hardinge Medical College (LHMC), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"2025121207263002309_j_hmbci-2016-0024_ref_001_w2aab3b8b2b1b7b1ab2b1b1Aa","unstructured":"Farid SM. 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