{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:30:14Z","timestamp":1765546214609,"version":"3.48.0"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_hmbci-2017-0010_s_999_w2aab3b8c14b1b7b1aab1c14b1Aa\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Recurrent pregnancy loss (RPL) is a heterogeneous disease which is defined as two or more consecutive fetal losses during early pregnancy. Interleukin-1 receptor antagonist (\n                      <jats:italic>IL-1Ra<\/jats:italic>\n                      ) is a anti-inflammatory cytokine, which inhibits\n                      <jats:italic>IL-1<\/jats:italic>\n                      activity by binding to its receptors. The aim of this study was to investigate the association between RPL and\n                      <jats:italic>IL-1Ra<\/jats:italic>\n                      intron 2 polymorphism (86 bp VNTR) in Iranian women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0010_s_998_w2aab3b8c14b1b7b1aab1c14b2Aa\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this case control study, genetic polymorphism was studied in 140 RPL patients and 140 healthy women as controls. Genomic DNA was extracted from the blood samples and polymorphism analysis was performed using the polymerase chain reaction (PCR) method. Finally, the data obtained were analyzed by statistical software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0010_s_997_w2aab3b8c14b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found an increased frequency of the IL-1Ra 1\/1 genotype in the case group compared to the control group. Whereas, the frequency of IL-1Ra genotype 1\/2 was higher in control group than in the case group. However, we did not observe an association between\n                      <jats:italic>IL-1Ra<\/jats:italic>\n                      86 bp VNTR polymorphism in intron 2 and RPL patients (p &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0010_s_996_w2aab3b8c14b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>IL-1Ra<\/jats:italic>\n                      VNTR polymorphism may not be a genetic factor for RPL. However, investigation of\n                      <jats:italic>IL-1Ra<\/jats:italic>\n                      polymorphism was recommended in other populations and patients with recurrent pregnancy loss.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/hmbci-2017-0010","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T09:15:31Z","timestamp":1496394931000},"source":"Crossref","is-referenced-by-count":10,"title":["Effects of interleukin-1 receptor antagonist (\n                    <i>IL-1Ra<\/i>\n                    ) gene 86 bp VNTR polymorphism on recurrent pregnancy loss: a case-control study"],"prefix":"10.1515","volume":"30","author":[{"given":"Yasamin Sayed","family":"Hajizadeh","sequence":"first","affiliation":[{"name":"Department of Microbiology , Urmia Branch, Islamic Azad University , Urmia , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Emami","sequence":"additional","affiliation":[{"name":"Department of Microbiology , Urmia Branch, Islamic Azad University , Urmia , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Nottagh","sequence":"additional","affiliation":[{"name":"Department of Genetic , Zanjan Branch, Islamic Azad University , Zanjan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Marine biology , Khorramshahr Marine Science and Technology University , Khorramshahr , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazila Fathi","family":"Maroufi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Medicine , Tabriz University of Medical Sciences , Tabriz , Iran"},{"name":"Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba Haj","family":"Azimian","sequence":"additional","affiliation":[{"name":"Department of Genetic , Tabriz Branch, Islamic Azad University , Tabriz , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Isazadeh","sequence":"additional","affiliation":[{"name":"Department of Genetic , Tabriz Branch, Islamic Azad University , Tabriz , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"2025121207275305750_j_hmbci-2017-0010_ref_001_w2aab3b8c14b1b7b1ab2b2aAa","doi-asserted-by":"crossref","unstructured":"Gupta R, Prakash S, Parveen F, Agrawal S. 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