{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:30:57Z","timestamp":1790807457701,"version":"4.1.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_hmbci-2017-0073_s_999_w2aab3b7ab1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d440067e304_w2aab3b7ab1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>The purpose of our study is to evaluate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with hormonal and metabolic parameters in patients with polycystic ovarian syndrome (PCOS) in order to assess whether these ratios may become useful tools during the evaluation of the severity of low grade inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0073_s_998_w2aab3b7ab1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d440067e313_w2aab3b7ab1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>The present study is based in secondary outcomes from a prospectively collected patient database. A total of 266 women with PCOS participated in this study and blood a complete blood count examination (CBC) that was used for the calculation of PLR and NLR was available in 182 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0073_s_997_w2aab3b7ab1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d440067e322_w2aab3b7ab1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>Association statistics revealed that PLR had a significant correlation to 17-OH progesterone (r = \u22120.177, p = 0.024) and Matsuda index values (r = 0.234, p = 0.009), whereas NLR was correlated with follicle stimulating hormone (FSH) (r = \u22120.204, p = 0.007), free testosterone (r = 320, p &lt; 0.001), \u03944-androstendione (r = 0.234, p = 0.003), sex hormone binding globulin (SHBG) (r = \u22120.350, p &lt; 0.002) and high-density lipoprotein (HDL) (r = \u22120.171, p = 0.039).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0073_s_996_w2aab3b7ab1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d440067e331_w2aab3b7ab1b6b1aab1c16b4aAa\">Conclusion<\/jats:title>\n                    <jats:p>According to the findings of our study, both PLR and NLR seem to be correlated with some hormonal and metabolic indices. This association is clearer in the case of NLR and serum androgens as it seems to be positively affected by their levels. PLR and NLR were not affected by the presence of obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/hmbci-2017-0073","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T18:16:23Z","timestamp":1524680183000},"source":"Crossref","is-referenced-by-count":18,"title":["Correlation of platelet to lymphocyte and neutrophil to lymphocyte ratio with hormonal and metabolic parameters in women with PCOS"],"prefix":"10.1515","volume":"34","author":[{"given":"Vasilios","family":"Pergialiotis","sequence":"first","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , University of Athens, Attikon University Hospital , Rimini 1 Chaidari , Athens, PC 12461 , Greece , Phone: +2105832244, Fax: +2105326447"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftihios","family":"Trakakis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , \u201cAttikon\u201d University Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Parthenis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , \u201cAttikon\u201d University Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erifili","family":"Hatziagelaki","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine , Research Institute and Diabetes Center, \u201cAttikon\u201d Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Chrelias","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , \u201cAttikon\u201d University Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Thomakos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , \u201cAttikon\u201d University Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Papantoniou","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology , \u201cAttikon\u201d University Hospital, National and Kapodistrian University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"2025121207392724387_j_hmbci-2017-0073_ref_001_w2aab3b7ab1b6b1ab1b6b1Aa","unstructured":"Ma YM, Li R, Qiao J, Zhang XW, Wang SY, Zhang QF, et al. Characteristics of abnormal menstrual cycle and polycystic ovary syndrome in community and hospital populations. Chin Med J (Engl). 2010;123:2185\u20139.20819662"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_002_w2aab3b7ab1b6b1ab1b6b2Aa","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19\u201325.14711538","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_003_w2aab3b7ab1b6b1ab1b6b3Aa","doi-asserted-by":"crossref","unstructured":"Al-Jefout M, Alnawaiseh N, Al-Qtaitat A. Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes. Sci Rep. 2017;7:5339.10.1038\/s41598-017-05717-y28706269","DOI":"10.1038\/s41598-017-05717-y"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_004_w2aab3b7ab1b6b1ab1b6b4Aa","doi-asserted-by":"crossref","unstructured":"Welty FK, Alfaddagh A, Elajami TK. Targeting inflammation in metabolic syndrome. Transl Res. 2016;167:257\u201380.10.1016\/j.trsl.2015.06.01726207884","DOI":"10.1016\/j.trsl.2015.06.017"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_005_w2aab3b7ab1b6b1ab1b6b5Aa","doi-asserted-by":"crossref","unstructured":"Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428\u201335.10.1038\/nature0720118650913","DOI":"10.1038\/nature07201"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_006_w2aab3b7ab1b6b1ab1b6b6Aa","doi-asserted-by":"crossref","unstructured":"Keskin Kurt R, Okyay AG, Hakverdi AU, Gungoren A, Dolapcioglu KS, Karateke A, et al. The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case \u2013 control study. Arch Gynecol Obstetr. 2014;290:315\u20139.10.1007\/s00404-014-3199-3","DOI":"10.1007\/s00404-014-3199-3"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_007_w2aab3b7ab1b6b1ab1b6b7Aa","doi-asserted-by":"crossref","unstructured":"Alanbay I, Ercan CM, Sakinci M, Coksuer H, Ozturk M, Tapan S. A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity? Arch Gynecol Obstetr. 2012;286:1065\u201371.10.1007\/s00404-012-2425-0","DOI":"10.1007\/s00404-012-2425-0"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_008_w2aab3b7ab1b6b1ab1b6b8Aa","doi-asserted-by":"crossref","unstructured":"Deligeoroglou E, Vrachnis N, Athanasopoulos N, Iliodromiti Z, Sifakis S, Iliodromiti S, et al. Mediators of chronic inflammation in polycystic ovarian syndrome. Gynecol Endocrinol. 2012;28:974\u20138.2255398310.3109\/09513590.2012.683082","DOI":"10.3109\/09513590.2012.683082"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_009_w2aab3b7ab1b6b1ab1b6b9Aa","doi-asserted-by":"crossref","unstructured":"Gonzalez F. Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids. 2012;77:300\u20135.10.1016\/j.steroids.2011.12.00322178787","DOI":"10.1016\/j.steroids.2011.12.003"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_010_w2aab3b7ab1b6b1ab1b6c10Aa","doi-asserted-by":"crossref","unstructured":"Cakiroglu Y, Vural F, Vural B. The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes. J Endocrinol Invest. 2016;39:899\u2013907.10.1007\/s40618-016-0446-426980590","DOI":"10.1007\/s40618-016-0446-4"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_011_w2aab3b7ab1b6b1ab1b6c11Aa","doi-asserted-by":"crossref","unstructured":"Trakakis E, Pergialiotis V, Hatziagelaki E, Panagopoulos P, Salloum I, Papantoniou N. Subclinical hypothyroidism does not influence the metabolic and hormonal profile of women with PCOS. Horm Mol Biol Clin Investig. 2017;31. doi:10.1515\/hmbci-2016-0058.28672734","DOI":"10.1515\/hmbci-2016-0058"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_012_w2aab3b7ab1b6b1ab1b6c12Aa","doi-asserted-by":"crossref","unstructured":"Nguyen DM, El-Serag HB. The epidemiology of obesity. Gastroenterol Clin North Am. 2010;39:1\u20137.2020257410.1016\/j.gtc.2009.12.014","DOI":"10.1016\/j.gtc.2009.12.014"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_013_w2aab3b7ab1b6b1ab1b6c13Aa","doi-asserted-by":"crossref","unstructured":"Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539\u201353.968669310.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_014_w2aab3b7ab1b6b1ab1b6c14Aa","doi-asserted-by":"crossref","unstructured":"Yilmaz MA, Duran C, Basaran M. The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. J Endocrinol Invest. 2016;39:45\u201353.10.1007\/s40618-015-0335-226100531","DOI":"10.1007\/s40618-015-0335-2"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_015_w2aab3b7ab1b6b1ab1b6c15Aa","unstructured":"Gonz\u00e1lez F, Daniels JK, Blair HE, Sreekumaran Nair K. Androgen administration stimulates reactive oxygen species generation from leukocytes of normal reproductive-age women. Reprod Sci. 2010;17:265A."},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_016_w2aab3b7ab1b6b1ab1b6c16Aa","doi-asserted-by":"crossref","unstructured":"Gonzalez F, Nair KS, Daniels JK, Basal E, Schimke JM. Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Am J Physiol Endocrinol Metab. 2012;302:E297\u2013306.2204531610.1152\/ajpendo.00416.2011","DOI":"10.1152\/ajpendo.00416.2011"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_017_w2aab3b7ab1b6b1ab1b6c17Aa","doi-asserted-by":"crossref","unstructured":"Escobar-Morreale HF, Luque-Ramirez M, Gonzalez F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril. 2011;95:1048-58 e1\u20132.","DOI":"10.1016\/j.fertnstert.2010.11.036"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_018_w2aab3b7ab1b6b1ab1b6c18Aa","doi-asserted-by":"crossref","unstructured":"Kelly CCJ, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N. Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metabol. 2001;86:2453\u20135.10.1210\/jcem.86.6.7580","DOI":"10.1210\/jcem.86.6.7580"},{"key":"2025121207392724387_j_hmbci-2017-0073_ref_019_w2aab3b7ab1b6b1ab1b6c19Aa","doi-asserted-by":"crossref","unstructured":"Nehir Aytan A, Bastu E, Demiral I, Bulut H, Dogan M, Buyru F. Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome. Gynecol Endocrinol. 2016;32:709\u201313.10.3109\/09513590.2016.115520826951881","DOI":"10.3109\/09513590.2016.1155208"}],"container-title":["Hormone Molecular Biology and Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/hmbci.ahead-of-print\/hmbci-2017-0073\/hmbci-2017-0073.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2017-0073\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2017-0073\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:12:47Z","timestamp":1765530767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/hmbci-2017-0073\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,4,25]]},"published-print":{"date-parts":[[2018,6,26]]}},"alternative-id":["10.1515\/hmbci-2017-0073"],"URL":"https:\/\/doi.org\/10.1515\/hmbci-2017-0073","relation":{},"ISSN":["1868-1891","1868-1883"],"issn-type":[{"value":"1868-1891","type":"electronic"},{"value":"1868-1883","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"article-number":"20170073"}}