{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:41:53Z","timestamp":1765528913884,"version":"3.48.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_hmbci-2017-0081_s_999_w2aab3b7b5b1b6b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A potential correlation between sex hormones, such as androgens and estrogens, and the development and progression of hepatocellular carcinoma (HCC) has been proposed. However, its details, in particular, aromatase status in diseased human liver has remained largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0081_s_998_w2aab3b7b5b1b6b1aab1c14b2Aa\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We immunolocalized aromatase, 17\u03b2-hydroxysteroid dehydrogenase (17\u03b2-HSD) type 1 and 17\u03b2-HSD type 2 in a total of 155 cases, consisting of normal liver (n = 10), nonalcoholic steatohepatitis (NASH) (n = 18), primary sclerosing cholangitis (PSC) (n = 6), primary biliary cholangitis (PBC) (n = 13), biliary atresia (n = 18), alcoholic hepatitis (n = 11), hepatitis C virus (HCV) (n = 31), HCV sustained virologic response (HCV-SVR) (n = 10), hepatitis B virus (HBV) (n = 20), HBV sustained virologic response (HBV-SVR) (n = 8) and infants (n = 10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0081_s_997_w2aab3b7b5b1b6b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Immunoreactivity scores of aromatase in HBV (59.5 \u00b1 30.9), HBV-SVR (68.1 \u00b1 33.5) and infants (100.5 \u00b1 36.6) were significantly higher than those in normal liver (26.0 \u00b1 17.1). Scores of 17\u03b2-HSD type 1 in any etiology other than HBV (116.3 \u00b1 23.7) and infants (120.0 \u00b1 28.5) were significantly lower than those in normal liver (122.5 \u00b1 8.6). Scores of 17\u03b2-HSD type 2 in NASH (74.4 \u00b1 36.6) were significantly lower than those in normal liver (128.0 \u00b1 29.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2017-0081_s_996_w2aab3b7b5b1b6b1aab1c14b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High immunoreactivity scores of aromatase and 17\u03b2-HSD type 1 in the patients with HBV suggest a correlation between HBV infection and in situ estrogen synthesis in hepatocytes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/hmbci-2017-0081","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T17:25:01Z","timestamp":1519838701000},"source":"Crossref","is-referenced-by-count":3,"title":["Aromatase in normal and diseased liver"],"prefix":"10.1515","volume":"41","author":[{"given":"Keigo","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Pathology , Tohoku University Hospital , 1-1 Seiryou-machi, Aoba-ku, Sendai 980-8574 , Japan , Phone: +81-22-7177440, Fax: +81-22-7177449"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuko","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Pathology, Tohoku Medical and Pharmaceutical University , Sendai , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Disaster Obstetrics and Gynecology , International Research Institute of Disaster Science , Tohoku University , Sendai , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Pathology , Tohoku University Hospital , Sendai , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"2025121207270595367_j_hmbci-2017-0081_ref_001_w2aab3b7b5b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Harada N, Ota H, Yoshimura N, Katsuyama T, Takagi Y. Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver. J Clin Endocrinol Metab. 1998;83:697\u2013702.","DOI":"10.1210\/jc.83.2.697"},{"key":"2025121207270595367_j_hmbci-2017-0081_ref_002_w2aab3b7b5b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Chen Z, Wang O, Nie M, Elison K, Zhou D, Li M, et al. Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism. Mol Cell Endocrinol. 2015;399:32\u201342.","DOI":"10.1016\/j.mce.2014.09.016"},{"key":"2025121207270595367_j_hmbci-2017-0081_ref_003_w2aab3b7b5b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Chen SA, Besman MJ, Sparkes RS, Zollman S, Klisak I, Mohandas T, et al. Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15. 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