{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:44:01Z","timestamp":1773891841525,"version":"3.50.1"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>COVID-19 emerged in Wuhan, China, but was caused by the original coronavirus, severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV2). In early 2020, there was a widespread breakout of cases well over world, resulting in an epidemic that rapidly escalated to become a pandemic. This abruptly shook the global healthcare system. The emergence of the alpha, beta, and delta SARS-CoV-2 were associated with new waves of infections, sometimes across the entire world but until this month i.e.,\u00a0between Nov-Dec, 2021, Delta variant reigned supreme until the emergence of a newer variant i.e., Omicron\u00a0(B.1.1.529) of SARS-CoV-2. Delta had 13 mutations. Of these, nine are in the spike protein, the protrusion on the\u00a0surface of\u00a0the virus that helps it latch onto human cells.\u00a0Specifically, two are in a molecular hook, called the \u201creceptor-binding\u00a0domain\u201d. Omicron, a creation caused by\u00a0monstrous mutations. At least 32 mutations are in the spike protein and 10 in the receptor-binding domain. was designated a COVID-19 variant of concern (VoC) by the World\u00a0Health Organization (WHO) on 26th November 2021. Structurally, the omicron variant has shown too mutated at antibody binding sites which would leverage them for escaping the possible immune response by the body. We don\u2019t yet know much about the other alterations and how they might affect the virus\u2019s behavior. Omicron COVID-19 strain after identifying individuals with symptoms that were not the same as those seen in the Delta form. People with night sweats have also been reported. The new omicron variant has more mutations than the prevailing rampant delta virus. This makes the newer variant more transmissible, better able to evade itself from various vaccines readily available in the current scenario. These overall increases in the percentage changes in a single day cases of COVID-19 reported cases can be attributed to the beginning of third wave or can be speculated as newer surge of omicron variant\u00a0cases. Yet another new variant has been detected in France\u00a0with 46 mutations and 37 deletions in its genetic code, many affecting the spike protein. \u2018B.1.640.2\u2019 is the current nomenclature for this variation.<\/jats:p>","DOI":"10.1515\/hmbci-2022-0010","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T19:39:32Z","timestamp":1662406772000},"page":"89-96","source":"Crossref","is-referenced-by-count":9,"title":["Omicron variant in COVID-19 current pandemic: a reason for apprehension"],"prefix":"10.1515","volume":"44","author":[{"given":"Prafull","family":"Kamble","sequence":"first","affiliation":[{"name":"Department of Physiology , All India Institute of Medical Sciences , Bibinagar , Telangana , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Daulatabad","sequence":"additional","affiliation":[{"name":"RVM Institute of Medical Sciences, Siddipet , Hyderabad , Telangana , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Patil","sequence":"additional","affiliation":[{"name":"Ashwini Rural Medical College, Hospital and Research Centre , Solapur , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8196-5634","authenticated-orcid":false,"given":"Nitin Ashok","family":"John","sequence":"additional","affiliation":[{"name":"Department of Physiology , All India Institute of Medical Sciences , Bibinagar , Telangana , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"John","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , All India Institute of Medical Sciences , Nagpur , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"2025121207255349055_j_hmbci-2022-0010_ref_001","unstructured":"World Health Organization. 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