{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:47:03Z","timestamp":1765529223348,"version":"3.48.0"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_hmbci-2022-0087_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Unexplained subfertility (UEI) describes a couple whose standard subfertility workout consider acceptable but unable to conceived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2022-0087_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted in the Advanced Reproductive Centre, UKM Hospital, Kuala Lumpur, from January 2016 to December 2019. The data of 268 UEI couples were obtained from the clinical database. Women aged 21\u201345 years old was included and further divided into four groups according to the female partner\u2019s age and subfertility duration: group A (age &lt;35 years and subfertility &lt;2 years), group B (age &lt;35 years and subfertility &gt;2 years), group C (age &gt;35 years and subfertility &lt;2 years), and group D (age &gt;35 years and subfertility &lt;2 years). All statistical analyses were performed using SPSS 22.0 for Windows.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2022-0087_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 255 cases were included in this study. The mean age of the women was 32.9\u00a0\u00b1\u00a04.04 years, and the mean subfertility duration was 5.04\u00a0\u00b1\u00a02.9 years. A total of 51 (20\u202f%) cases underwent timed sexual intercourse, 147 (57.6\u202f%) cases had intrauterine insemination (IUI), whereas 57 (22.4\u202f%) cases opted for\n                      <jats:italic>in\u00a0vitro<\/jats:italic>\n                      fertilization (IVF). A total of 204 cases underwent active management (IUI\/IVF), which showed a\u00a0significant difference (p&lt;0.05). Out of eight clinical pregnancies, half of them were from group B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_hmbci-2022-0087_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Active management in younger women with a\u00a0shorter subfertility duration revealed a better pregnancy outcome. Otherwise, individualized treatment should be considered in selecting a suitable treatment plan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/hmbci-2022-0087","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:43:40Z","timestamp":1703130220000},"page":"379-384","source":"Crossref","is-referenced-by-count":2,"title":["Unexplained subfertility: active or conservative management?"],"prefix":"10.1515","volume":"44","author":[{"given":"Siti Maisarah","family":"Ahmad","sequence":"first","affiliation":[{"name":"Advanced Reproductive Centre, Faculty of Medicine (ARC) , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"},{"name":"Reproductive Unit , Hospital Tuanku Azizah (HTA) , Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norazilah","family":"Mat Jin","sequence":"additional","affiliation":[{"name":"Advanced Reproductive Centre, Faculty of Medicine (ARC) , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Teknologi MARA (UiTM) , National University of Malaysia (UKM) , Selangor , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Faizal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Advanced Reproductive Centre, Faculty of Medicine (ARC) , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"},{"name":"Reproductive Unit , Hospital Tuanku Azizah (HTA) , Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Kadir","family":"Abdul Karim","sequence":"additional","affiliation":[{"name":"Advanced Reproductive Centre, Faculty of Medicine (ARC) , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-572X","authenticated-orcid":false,"given":"Muhammad Azrai","family":"Abu","sequence":"additional","affiliation":[{"name":"Advanced Reproductive Centre, Faculty of Medicine (ARC) , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine , National University of Malaysia (UKM) , Kuala Lumpur , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"2025121207283340013_j_hmbci-2022-0087_ref_001","doi-asserted-by":"crossref","unstructured":"Ray, A, Shah, A, Gudi, A, Homburg, R. 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