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Progesterone is highly important in the regulation of menstrual bleeding and a progesterone-deficient anovulatory state is a common cause of DUB. There are a wide range of treatment options available including hormonal therapies (oral cyclical progestogens, depot progestogens, progestogen-releasing intrauterine devices, combined oral contraceptives, danazol, gonadotrophin-releasing hormone analogues and hormone replacement therapy), non-hormonal therapies (non-steroidal anti-inflammatory drugs and antifibrinolytic drugs) and surgery (hysterectomy and endometrial ablation). The choice of appropriate therapy should be based on factors such as the mechanism behind the DUB, which symptoms are most problematic, and the woman's need for fertility or contraception. However, there is currently a lack of clinical evidence to help support these decisions.<\/jats:p>","DOI":"10.1515\/hmbci.2010.043","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T05:35:13Z","timestamp":1294896913000},"page":"461-467","source":"Crossref","is-referenced-by-count":2,"title":["Dysfunctional uterine bleeding: from adolescence to menopause"],"prefix":"10.1515","volume":"3","author":[{"given":"R\u00e9ne","family":"Druckmann","sequence":"first","affiliation":[{"name":"22 rue Gounod, F-06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1067\/mob.2001.111795","volume":"184","author":"Nicholson WK","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/bmj.323.7303.24","volume":"323","author":"Warner 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