{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:50:21Z","timestamp":1765525821480,"version":"3.48.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hormone Molecular Biology and Clinical Investigation"],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    One hundred and eighty-five women with a mean age of 50.71 (SD=5.58) years upon initiation of treatment were studied before, and during, treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    Included in the profile of patients under study were family and personal histories, gynecological and breast examinations. Population age: a) &lt;60\u00a0years old, 171 women (92.43%), and b) aged 60\u00a0years or older, 14 women (7.57%). Dosage comprised both 0.625\u00a0mg\/daily orally of conjugated equine estrogens and 2.5 or 5\u00a0mg\/daily of medroxy progesterone acetate. No further specific treatment was prescribed. Mean duration of treatment was 9.82 (SD=5.42) years for all women; 9.70 (SD=5.44) in the younger group. Follow-up comprised 1815.84 woman-years, for 5 years or over (76.75%) on 142 women. Fifty-two women (28.11%) dropped out.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    No deaths occurred during treatment. Four cardiovascular events (2.16%) were reported. No spontaneous bone fracture was documented. Nonetheless, there were 12 bone fractures of traumatic origin (6.48%), none of them hip fractures. Five breast cancers were observed. Likewise, one diagnosis of breast cancer for every 37 treated women from our series was evidenced. There were 117 women (63.24%) without any events.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    A higher risk of breast cancer or of serious cardiovascular events cannot be inferred from statistical analysis of 5 years or more of treatment.\n                  <\/jats:p>","DOI":"10.1515\/hmbci.2011.111","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T06:42:40Z","timestamp":1317019360000},"page":"479-490","source":"Crossref","is-referenced-by-count":0,"title":["Hormone replacement therapy: 1815.84 woman-years of follow-up main clinical events"],"prefix":"10.1515","volume":"8","author":[{"given":"Joaqu\u00edn","family":"Cort\u00e9s-Prieto","sequence":"first","affiliation":[{"name":"Gynecology Department of Medical Specialities, Medical School, University of Alcala, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lina","family":"Vicente-Hernanz","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operational Research III School of Statistics, Complutense University of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Cort\u00e9s-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gynecology Department of Medical Specialities, Medical School, University of Alcala, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Ahern","sequence":"additional","affiliation":[{"name":"Biostatistics, Department of Sanitary and Socio-Medical Sciences, Medical School, University of Alcala, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"p_1","first-page":"373","author":"Marsden J","year":"2000","journal-title":"New York-Basel: Marcel Dekker"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-197907000-00017"},{"key":"p_3","first-page":"435","volume":"62","author":"Gambrell","year":"1983","journal-title":"Obstet Gynecol"},{"key":"p_4","first-page":"133","author":"Byyny RL","year":"1990","journal-title":"Sydney: Williams and Wilkins"},{"key":"p_5","first-page":"827","volume":"80","author":"Nachtigall MJ","year":"1992","journal-title":"Obstet Gynecol"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.273.3.199"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08233-0"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00078-1"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.4.328"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506153322401"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<339::AID-IJC5>3.0.CO;2-6"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14065-2"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.24.3254"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.201"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2004.30281.x"},{"key":"p_20","first-page":"11","author":"Pasqualini JR","year":"2008","journal-title":"Informa Healthcare USA Inc."},{"key":"p_21","first-page":"343","author":"Kloosterboer HJ","year":"2008","journal-title":"Informa Healthcare USA Inc."},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1515\/HMBCI.2010.015"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2007.12.002"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01010"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01453-3"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.041"},{"key":"p_27","first-page":"139","volume":"1997","author":"Doherty JA","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"p_29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5694\/j.1326-5377.1988.tb99424.x","volume":"148","author":"Armstrong BK","year":"1988","journal-title":"Med J Aust"},{"key":"p_30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/cmt.5.3.211.216","volume":"5","author":"Schneider HPG","year":"2002","journal-title":"Climacteric"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.085"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.12.001"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.18.1541"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1001\/jama.253.13.1908"},{"key":"p_36","doi-asserted-by":"crossref","first-page":"754","DOI":"10.7326\/0003-4819-134-9_Part_1-200105010-00012","volume":"134","author":"Binder EF","year":"2001","journal-title":"Ann Intern Med"},{"key":"p_37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.7326\/0003-4819-131-12-199912210-00005","volume":"131","author":"Ravn I","year":"1999","journal-title":"Ann Intern Med"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.021"}],"container-title":["hmbci"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/HMBCI.2011.111\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/HMBCI.2011.111\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:45:59Z","timestamp":1765525559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/HMBCI.2011.111\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,26]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,1]]}},"alternative-id":["10.1515\/HMBCI.2011.111"],"URL":"https:\/\/doi.org\/10.1515\/hmbci.2011.111","relation":{},"ISSN":["1868-1891","1868-1883"],"issn-type":[{"type":"electronic","value":"1868-1891"},{"type":"print","value":"1868-1883"}],"subject":[],"published":{"date-parts":[[2011,9,26]]}}}