{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:25:07Z","timestamp":1791872707622,"version":"4.3.4"},"reference-count":176,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:italic>Vibrio cholerae<\/jats:italic> is a Gram-negative bacterium that lives in brackish or sea water environments. Strains of <jats:italic>V. cholerae<\/jats:italic> carrying the pathogenicity islands infect the human gut and cause the fatal disease cholera. <jats:italic>Vibrio cholerae<\/jats:italic> maintains a Na<jats:sup>+<\/jats:sup> gradient at its cytoplasmic membrane that drives substrate uptake, motility, and efflux of antibiotics. Here, we summarize the major Na<jats:sup>+<\/jats:sup>-dependent transport processes and describe the central role of the Na<jats:sup>+<\/jats:sup>-translocating NADH:quinone oxidoreductase (Na<jats:sup>+<\/jats:sup>-NQR), a primary Na<jats:sup>+<\/jats:sup> pump, in maintaining a Na<jats:sup>+<\/jats:sup>-motive force. The Na<jats:sup>+<\/jats:sup>-NQR is a membrane protein complex with a mass of about 220 kDa that couples the exergonic oxidation of NADH to the transport of Na<jats:sup>+<\/jats:sup> across the cytoplasmic membrane. We describe the molecular architecture of this respiratory complex and summarize the findings how electron transport might be coupled to Na<jats:sup>+<\/jats:sup>-translocation. Moreover, recent advances in the determination of the three-dimensional structure of this complex are reported.<\/jats:p>","DOI":"10.1515\/hsz-2014-0204","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T08:00:00Z","timestamp":1409644800000},"page":"1389-1399","source":"Crossref","is-referenced-by-count":29,"title":["Central role of the Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) in sodium bioenergetics of Vibrio cholerae"],"prefix":"10.1515","volume":"395","author":[{"given":"Julia","family":"Steuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Halang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vorburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojtek","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Vohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1661","first-page":"89","article-title":"Insights into the biochemistry of the ubiquitous NhaP family of cation antiporters","author":"Resch","year":"2011","journal-title":"Biochem Cell Biol"},{"key":"ref321","first-page":"244","article-title":"van Binding of by cholera toxin","author":"Galloway","year":"1987","journal-title":"Biochem J"},{"key":"ref1741","first-page":"62","article-title":"Crystallization of the NADH - 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