{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:04:08Z","timestamp":1791173048598,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human cysteine cathepsins (family C1, clan CA) have long been regarded as ubiquitous household enzymes, primarily involved in the recycling and degradation of proteins in lysosomes. This opinion has changed considerably during recent decades, however, with the demonstration of their involvement in various physiological processes. A growing body of evidence supports the theory that cathepsins play specific functions in lung homeostasis and pathophysiological events such as asthma, lung fibrosis (including idiopathic pulmonary fibrosis), chronic obstructive pulmonary disease (embracing emphysema and chronic bronchitis), silicosis, bronchopulmonary dysplasia or tumor invasion. The objective of this review is to provide an update on the current knowledge of the role of these enzymes in the lung. Particular attention has been paid to the understanding of the role of these proteases and their natural inhibitors, cystatins (family I25, clan IH), in TGF-\u03b21-driven fibrotic processes with an emphasis on lung fibrosis.<\/jats:p>","DOI":"10.1515\/hsz-2014-0210","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T10:01:40Z","timestamp":1409220100000},"page":"111-130","source":"Crossref","is-referenced-by-count":51,"title":["Cysteine cathepsins and cystatins: from ancillary tasks to prominent status in lung diseases"],"prefix":"10.1515","volume":"396","author":[{"given":"Gilles","family":"Lalmanach","sequence":"first","affiliation":[{"name":"INSERM U1100 \u2018Pathologies Pulmonaires: Prot\u00e9olyse et A\u00e9rosolth\u00e9rapie\u2019, Equipe M\u00e9canismes Prot\u00e9olytiques dans l\u2019Inflammation\/Centre d\u2019Etude des Pathologies Respiratoires, Universit\u00e9 Fran\u00e7ois Rabelais, Facult\u00e9 de M\u00e9decine, 10 Boulevard Tonnell\u00e9, F-37032 Tours cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlame","family":"Saidi","sequence":"additional","affiliation":[{"name":"INSERM U1100 \u2018Pathologies Pulmonaires: Prot\u00e9olyse et A\u00e9rosolth\u00e9rapie\u2019, Equipe M\u00e9canismes Prot\u00e9olytiques dans l\u2019Inflammation\/Centre d\u2019Etude des Pathologies Respiratoires, Universit\u00e9 Fran\u00e7ois Rabelais, Facult\u00e9 de M\u00e9decine, 10 Boulevard Tonnell\u00e9, F-37032 Tours cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Marchand-Adam","sequence":"additional","affiliation":[{"name":"INSERM U1100 \u2018Pathologies Pulmonaires: Prot\u00e9olyse et A\u00e9rosolth\u00e9rapie\u2019, Equipe M\u00e9canismes Prot\u00e9olytiques dans l\u2019Inflammation\/Centre d\u2019Etude des Pathologies Respiratoires, Universit\u00e9 Fran\u00e7ois Rabelais, Facult\u00e9 de M\u00e9decine, 10 Boulevard Tonnell\u00e9, F-37032 Tours cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Lecaille","sequence":"additional","affiliation":[{"name":"INSERM U1100 \u2018Pathologies Pulmonaires: Prot\u00e9olyse et A\u00e9rosolth\u00e9rapie\u2019, Equipe M\u00e9canismes Prot\u00e9olytiques dans l\u2019Inflammation\/Centre d\u2019Etude des Pathologies Respiratoires, Universit\u00e9 Fran\u00e7ois Rabelais, Facult\u00e9 de M\u00e9decine, 10 Boulevard Tonnell\u00e9, F-37032 Tours cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Kasabova","sequence":"additional","affiliation":[{"name":"INSERM U1100 \u2018Pathologies Pulmonaires: Prot\u00e9olyse et A\u00e9rosolth\u00e9rapie\u2019, Equipe M\u00e9canismes Prot\u00e9olytiques dans l\u2019Inflammation\/Centre d\u2019Etude des Pathologies Respiratoires, Universit\u00e9 Fran\u00e7ois Rabelais, Facult\u00e9 de M\u00e9decine, 10 Boulevard Tonnell\u00e9, F-37032 Tours cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,1,10]]},"container-title":["Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bchm.2015.396.issue-2\/hsz-2014-0210\/hsz-2014-0210.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2014-0210\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2014-0210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T15:22:45Z","timestamp":1647271365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2014-0210\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,1,10]]},"published-print":{"date-parts":[[2015,2,1]]}},"alternative-id":["10.1515\/hsz-2014-0210"],"URL":"https:\/\/doi.org\/10.1515\/hsz-2014-0210","relation":{},"ISSN":["1437-4315","1431-6730"],"issn-type":[{"value":"1437-4315","type":"electronic"},{"value":"1431-6730","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,10]]}}}