{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:53:58Z","timestamp":1784951638018,"version":"3.55.0"},"reference-count":312,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bipolar disorder (BD) is a severe psychiatric disorder that affects up to 15% of the worldwide population. Characterized by switches in mood between mania and depression, its etiology is still unknown and efforts have been made to elucidate the mechanisms involved in first episode, development and progression of the disorder. Microglia activation, abnormal activity of GSK-3\u03b2 and reduction in neurotrophic factor expression related to neuroinflammatory processes have been indicated to be part of the disorder\u2019s pathophysiology. Lithium, the main mood stabilizer used for the treatment and prevention of relapses, acts as an anti-inflammatory agent. Based on that, here we suggest a neuroinflammatory pathway for would be BD progression, in which microglia activation states modulated via constitutive induction of kinin-B1 receptor and reduction of kinin-B2 receptor expression and activity.<\/jats:p>","DOI":"10.1515\/hsz-2015-0257","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T12:33:44Z","timestamp":1455107624000},"page":"283-296","source":"Crossref","is-referenced-by-count":40,"title":["Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis"],"prefix":"10.1515","volume":"397","author":[{"given":"Yahaira M.","family":"Naaldijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref2141","first-page":"2015","article-title":"Berberine alleviates cardiac ischemia \/ reperfusion injury by inhibiting excessive autophagy in cardiomyocytes","author":"Huang","journal-title":"Eur J Pharmacol"},{"key":"ref101","first-page":"355","article-title":"single nucleotide polymorphism in glycogen synthase kinase - 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