{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:32:44Z","timestamp":1776774764861,"version":"3.51.2"},"reference-count":183,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies. JCPyV is a DNA tumor virus with a double-stranded DNA genome and encodes a well-studied oncogene, large T antigen. Its host range is highly restricted to humans and only a few cell types support lytic infection\n                    <jats:italic>in vivo<\/jats:italic>\n                    or\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Its oncogenic potential in humans has not been firmly established and the international committee on oncogenic viruses lists JCPyV as possibly carcinogenic. Significant progress has been made in understanding the biology of JCPyV and here we present an overview of the field and discuss some important questions that remain unanswered.\n                  <\/jats:p>","DOI":"10.1515\/hsz-2016-0345","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T08:47:28Z","timestamp":1494492448000},"page":"839-855","source":"Crossref","is-referenced-by-count":74,"title":["The biology of JC polyomavirus"],"prefix":"10.1515","volume":"398","author":[{"given":"Benedetta","family":"Assetta","sequence":"first","affiliation":[{"name":"Graduate Program in Pathobiology , Brown University , Providence , RI 02912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-9073","authenticated-orcid":false,"given":"Walter J.","family":"Atwood","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Cell Biology and Biochemistry , Brown University , 70 Ship Street, Box G-E434 , Providence , RI 02912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"key":"2026013016180975176_j_hsz-2016-0345_ref_001_w2aab3b7c15b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ahmed, W., Wan, C., Goonetilleke, A., and Gardner, T. (2010). Evaluating sewage-associated JCV and BKV polyomaviruses for sourcing human fecal pollution in a coastal river in Southeast Queensland, Australia. J. Environ. Qual. 39, 1743\u20131750.","DOI":"10.2134\/jeq2010.0062"},{"key":"2026013016180975176_j_hsz-2016-0345_ref_002_w2aab3b7c15b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Aksamit, A.J., Major, E.O., Ghatak, N.R., Sidhu, G.S., Parisi, J.E., and Guccion, J.G. (1987). Diagnosis of progressive multifocal leukoencephalopathy by brain biopsy with biotin labeled DNA:DNA in situ hybridization. J. Neuropathol. Exp. Neurol. 46, 556\u2013566.","DOI":"10.1097\/00005072-198709000-00005"},{"key":"2026013016180975176_j_hsz-2016-0345_ref_003_w2aab3b7c15b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Allander, T., Andreasson, K., Gupta, S., Bjerkner, A., Bogdanovic, G., Persson, M.A., Dalianis, T., Ramqvist, T., and Andersson, B. (2007). Identification of a third human polyomavirus. J. 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