{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:24:34Z","timestamp":1773159874981,"version":"3.50.1"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aimed to explore the regulation of heat shock protein 47 (HSP47) on expressions of receptors associated with hepatic stellate cell (HSC) in liver fibrosis mouse models induced by<jats:italic>Schistosoma japonicum<\/jats:italic>(<jats:italic>S. japonicum<\/jats:italic>). Mouse fibroblasts (NIH\/3T3) were transfected with HSP47 shRNA plasmid by lipofectamine transfection, and experimental fibrosis in HSCs was studied in<jats:italic>S. japonicum<\/jats:italic>mouse models treated with HSP47 shRNA<jats:italic>in vivo<\/jats:italic>. HSP47 expression was assessed using Western blot and real-time PCR. Flow cytometry was adopted to determine the expression of cell membrane receptors. HSP47-shRNA could markedly down-regulate the expression of collagen (Col1a1 and Col3a1). The expressions of HSP47, endothelin receptor A (ETAR) and endothelin receptor B (ETBR) significantly increased in the liver tissue of infected mice. However, the expressions of ETAR and HSP47 and ETBR remarkably decreased after the administration of HSP47 shRNA<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. ETAR and ETBR levels were found to be positively correlated with HSP47 expression. HSP47 might exert influence on liver fibrosis via the regulation of ETAR and ETBR.<\/jats:p>","DOI":"10.1515\/hsz-2017-0177","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T10:00:45Z","timestamp":1502532045000},"page":"1357-1366","source":"Crossref","is-referenced-by-count":15,"title":["Heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of Schistosoma japonicum-infected mice"],"prefix":"10.1515","volume":"398","author":[{"given":"Yumin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisheng","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigui","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref231","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0002-9440(10)62522-9","article-title":"Enhanced expression of endothelin B receptor at protein and gene levels in human cirrhotic liver","volume":"159","year":"2001","journal-title":"Am. 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