{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:49:04Z","timestamp":1790650144177,"version":"4.1.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The crude venom of the giant ant <jats:italic>Dinoponera quadriceps<\/jats:italic> is a cocktail of polypeptides and organic compounds that shows antiparasitic effects against <jats:italic>Trypanosoma cruzi<\/jats:italic>, the causative agent of Chagas disease. In order to investigate the venom-derived components responsible for such antitrypanosomal activity, four dinoponeratoxins (DnTxs) were identified, namely M-PONTX-Dq3a, -Dq3b, -Dq3c and -Dq4e, that are diverse in size, net charge, hydrophobicity and propensity to interact with eukaryote cell membranes. These peptides were tested against epimastigote, trypomastigote and amastigote forms of benznidazole (Bz)-resistant Y strain of <jats:italic>T. cruzi<\/jats:italic> and in mammalian host cells. The M-PONTX-Dq3a and -Dq4e inhibited all developmental forms of <jats:italic>T. cruzi<\/jats:italic>, including amastigotes, the responsible form for the maintenance of infection on chronic phase of the disease. The M-PONTX-Dq3a showed the highest selectivity index (SI) (80) and caused morphological alterations in <jats:italic>T. cruzi<\/jats:italic>, as observed by scanning electron microscopy (SEM), and induced cell death through necrosis, as seen by multiparametric flow cytometry analysis with specific biochemical markers. Altogether, the <jats:italic>D. quadriceps<\/jats:italic> venom appears as a source for the prospection of trypanocidal peptides and the M-PONTX-Dq3a arises as a candidate among the dinoponeratoxin-related peptides in the development of compounds against Chagas disease.<\/jats:p>","DOI":"10.1515\/hsz-2017-0198","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:05:19Z","timestamp":1507111519000},"page":"187-196","source":"Crossref","is-referenced-by-count":38,"title":["The dinoponeratoxin peptides from the giant ant <i>Dinoponera quadriceps<\/i> display <i>in vitro<\/i> antitrypanosomal activity"],"prefix":"10.1515","volume":"399","author":[{"given":"D\u00e2nya Bandeira","family":"Lima","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy , Department of Clinical and Toxicological Analysis , Federal University of Cear\u00e1, Rua Capit\u00e3o Francisco Pedro 1210 , 60430-372 Fortaleza\/CE , Brazil"},{"name":"Program of Post-Graduation in 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