{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:09:22Z","timestamp":1790096962898,"version":"4.0.1"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vaginal cancer is rare and largely unexplored. We found here that kallikrein-related peptidase 5 (KLK5) is coordinately expressed along with other KLKs in all stratified epithelia, including vagina, pointing to potential role(s) in differentiation. Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that <jats:italic>Klk5<\/jats:italic>\n                  <jats:sup>\u2212\/\u2212<\/jats:sup> mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene. Nf-\u03bab activation is markedly enhanced in <jats:italic>Klk5<\/jats:italic>\n                  <jats:sup>\u2212\/\u2212<\/jats:sup>, leading to increased resistance to apoptosis of mutated vaginal cells. This explains the higher tumor numbers observed in <jats:italic>Klk5<\/jats:italic>\n                  <jats:sup>\u2212\/\u2212<\/jats:sup> compared to wildtype. Thus, KLK5 may represent a putative suppressor of vaginal cancer.<\/jats:p>","DOI":"10.1515\/hsz-2017-0302","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T09:32:48Z","timestamp":1521711168000},"page":"1107-1111","source":"Crossref","is-referenced-by-count":11,"title":["KLK5, a novel potential suppressor of vaginal carcinogenesis"],"prefix":"10.1515","volume":"399","author":[{"given":"Georgios","family":"Pampalakis","sequence":"first","affiliation":[{"name":"Department of Pharmacy , School of Health Sciences , University of Patras , GR-265 04 Rion-Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Zingkou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , School of Health Sciences , University of Patras , GR-265 04 Rion-Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Sotiropoulou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , School of Health Sciences , University of Patras , GR-265 04 Rion-Patras , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"2023033115190623057_j_hsz-2017-0302_ref_001_w2aab3b7c10b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Anisimov, V.N., Zabezhinski, M.A., Popovich, I.G., Zaripova, E.A., Musatov, S.A., Andre, V., Vigreux, C., Godard, T., and Sichel, F. 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