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Both direct and indirect methods to treat cancer cells with NTP have been developed. NTP interacts directly with not only cancer cells but also the liquids surrounding cancer cells and the immune cells that target them. Reactive oxygen and nitrogen species play key roles in NTP-induced effects; however, other mechanisms have been suggested. The complex interactions between NTP, cells and liquids have been extensively studied. In the future, details regarding NTP-induced effects on gene regulatory networks, signaling networks, and metabolic networks will be elucidated.<\/jats:p>","DOI":"10.1515\/hsz-2018-0199","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T09:02:23Z","timestamp":1538816543000},"page":"87-91","source":"Crossref","is-referenced-by-count":46,"title":["Molecular mechanisms of non-thermal plasma-induced effects in cancer cells"],"prefix":"10.1515","volume":"400","author":[{"given":"Hiromasa","family":"Tanaka","sequence":"first","affiliation":[{"name":"Institute of Innovation for Future Society , Nagoya University , Furo-cho, Chikusa-ku, Nagoya 464-8603 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Center for Advanced Medicine and Clinical Research , Nagoya University Hospital , Tsurumai-cho 65 , Showa-ku, Nagoya 466-8550 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Plasma Nanotechnology Research Center , Nagoya University , Furo-cho, Chikusa-ku, Nagoya 464-8603 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Toyokuni","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses , Nagoya University Graduate School of Medicine , Tsurumai-cho 65 , Showa-ku, Nagoya 466-8550 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Tsurumai-cho 65 , Showa-ku, Nagoya 466-8550 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Kikkawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Nagoya University Graduate School of Medicine , Tsurumai-cho 65 , Showa-ku, Nagoya 466-8550 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Hori","sequence":"additional","affiliation":[{"name":"Institute of Innovation for Future Society , Nagoya University , Furo-cho, Chikusa-ku, Nagoya 464-8603 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"2023040406493609208_j_hsz-2018-0199_ref_001_w2aab3b7c11b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Adachi, T., Tanaka, H., Nonomura, S., Hara, H., Kondo, S.I., and Hori, M. 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