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Interestingly, metastatic melanoma cells rely on glutaminolysis rather than aerobic glycolysis for their bioenergetic needs through the tricarboxylic acid (TCA) cycle. Here, we compared the effects of glucose or glutamine on melanoma cell proliferation, migration and oxidative phosphorylation <jats:italic>in vitro<\/jats:italic>. We found that glutamine-driven melanoma cell\u2019s aggressive traits positively correlated with increased expression of HIF1\u03b1 and its pro-autophagic target BNIP3. BNIP3 silencing reduced glutamine-mediated effects on melanoma cell growth, migration and bioenergetics. Hence, BNIP3 is a vital component of the mitochondria quality control required for glutamine-driven melanoma aggressiveness.<\/jats:p>","DOI":"10.1515\/hsz-2018-0208","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T22:16:11Z","timestamp":1529532971000},"page":"187-193","source":"Crossref","is-referenced-by-count":24,"title":["BNIP3 contributes to the glutamine-driven aggressive behavior of melanoma cells"],"prefix":"10.1515","volume":"400","author":[{"given":"Monica","family":"Vara-Perez","sequence":"first","affiliation":[{"name":"Cell Death Research and Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine , O&N1 Building from Campus Gasthuisberg, KU Leuven University of Leuven , Herenstraat 49 , B-3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Maes","sequence":"additional","affiliation":[{"name":"Cell Death Research and Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine , O&N1 Building from Campus Gasthuisberg, KU Leuven University of Leuven , Herenstraat 49 , B-3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Van Dingenen","sequence":"additional","affiliation":[{"name":"Cell Death Research and Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine , O&N1 Building from Campus Gasthuisberg, KU Leuven University of Leuven , Herenstraat 49 , B-3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Agostinis","sequence":"additional","affiliation":[{"name":"Cell Death Research and Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine , O&N1 Building from Campus Gasthuisberg, KU Leuven University of Leuven , Herenstraat 49 , B-3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"2023040406474865812_j_hsz-2018-0208_ref_001_w2aab3b7c32b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Bettum, I.J., Gorad, S.S., Barkovskaya, A., Pettersen, S., Moestue, S.A., Vasiliauskaite, K., Tenstad, E., Oyjord, T., Risa, O., Nygaard, V., et al. (2015). Metabolic reprogramming supports the invasive phenotype in malignant melanoma. Cancer Lett. 366, 71\u201383.","DOI":"10.1016\/j.canlet.2015.06.006"},{"key":"2023040406474865812_j_hsz-2018-0208_ref_002_w2aab3b7c32b1b6b1ab2ab2Aa","doi-asserted-by":"crossref","unstructured":"Dang, C.V., Kim, J.W., Gao, P., and Yustein, J. (2008). The interplay between MYC and HIF in cancer. Nat. Rev. Cancer 8, 51\u201356.","DOI":"10.1038\/nrc2274"},{"key":"2023040406474865812_j_hsz-2018-0208_ref_003_w2aab3b7c32b1b6b1ab2ab3Aa","doi-asserted-by":"crossref","unstructured":"Demirsoy, S., Martin, S., Maes, H., and Agostinis, P. (2016). Adapt, recycle, and move on: proteostasis and trafficking mechanisms in melanoma. Front. 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