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In the light of this difficulty, the creation of isoenzyme-selectivity is one of the major challenges in the development of HDAC inhibitors. In a series of trifluoromethylketone inhibitors of HDAC8 compound <jats:bold>10<\/jats:bold> shows a distinct binding mechanism and a dramatically increased residence time (RT) providing kinetic selectivity against HDAC4. Combining the binding kinetics results with computational docking and binding site flexibility analysis suggests that <jats:bold>10<\/jats:bold> occupies the conserved catalytic site as well as an adjacent transient sub-pocket of HDAC8.<\/jats:p>","DOI":"10.1515\/hsz-2018-0363","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T09:01:07Z","timestamp":1544086867000},"page":"733-743","source":"Crossref","is-referenced-by-count":8,"title":["Kinetically selective and potent inhibitors of HDAC8"],"prefix":"10.1515","volume":"400","author":[{"given":"Markus","family":"Schweipert","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology , University of Applied Sciences Darmstadt , Stephanstr. 7 , 64295 Darmstadt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"J\u00e4nsch","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology , University of Applied Sciences Darmstadt , Stephanstr. 7 , 64295 Darmstadt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisely Oki","family":"Sugiarto","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology , University of Applied Sciences Darmstadt , Stephanstr. 7 , 64295 Darmstadt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz-Josef","family":"Meyer-Almes","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology , University of Applied Sciences Darmstadt , Stephanstr. 7 , 64295 Darmstadt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"2023040406521822689_j_hsz-2018-0363_ref_001_w2aab3b7c38b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Akaike, H. 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