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AhR\u2019s ability to target transporters within the kidney is essentially unexplored. We show here that exposing isolated killifish (<jats:italic>Fundulus heteroclitus<\/jats:italic>) renal proximal tubules to micromolar \u03b2<jats:italic>-<\/jats:italic>naphthoflavone (BNF) or nanomolar TCDD roughly doubled the transport activity of Multidrug resistance-associated proteins Mrp2 and Mrp4, P-glycoprotein (P-gp) and Breast cancer resistance protein (Bcrp), all ATP-driven xenobiotic efflux pumps and critical determinants of renal xenobiotic excretion. These effects were abolished by actinomycin D and cycloheximide and by the AhR antagonist, \u03b1-naphthoflavone, indicating that increased transport activity was dependent on transcription and translation as well as ligand binding to AhR. Quantitative immunostaining of renal tubules exposed to BNF and TCDD showed increased luminal membrane expression of Mrp2, Mrp4, P-gp and Bcrp. Thus, in these renal tubules, the four ABC transporters are targets of AhR action.<\/jats:p>","DOI":"10.1515\/hsz-2018-0425","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T09:07:18Z","timestamp":1553591238000},"page":"1335-1345","source":"Crossref","is-referenced-by-count":17,"title":["Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (<i>Fundulus heteroclitus<\/i>) renal proximal tubules"],"prefix":"10.1515","volume":"400","author":[{"given":"Anne","family":"Mahringer","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology , Ruprecht-Karls-University , D-69120 Heidelberg , Germany"},{"name":"Mount Desert Island Biological Laboratory (MDIBL) , Salisbury Cove, ME 04672 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Bernd","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology , Ruprecht-Karls-University , D-69120 Heidelberg , Germany"},{"name":"Mount Desert Island Biological Laboratory (MDIBL) , Salisbury Cove, ME 04672 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Mount Desert Island Biological Laboratory (MDIBL) , Salisbury Cove, ME 04672 , USA"},{"name":"Laboratory of Toxicology and Pharmacology and Chemistry , National Institutes of Health\/National Institute of Environmental Health Sciences , Research Triangle Park, NC 27709 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Fricker","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology , Ruprecht-Karls-University , D-69120 Heidelberg , Germany"},{"name":"Mount Desert Island Biological Laboratory , Salisbury Cove, ME 04672 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"2023040406460749360_j_hsz-2018-0425_ref_001_w2aab3b7b8b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Adedoyin, A., Aarons, L., and Houston, J.B. 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