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Most of the patients have abdominal\/pelvic invasion and metastasis at the time of diagnosis, but the underlying mechanism remains unclear. Insufficiency of blood perfusion and diffusion within most solid tumors can lead to a hypoxic tumor microenvironment and promotes tumor malignancy. In the present study, we detected the role of the spermatogenesis- and oogenesis-specific basic helix-loop-helix (bHLH) transcription factor 2 (sohlh2) on migration, invasion and epithelial-mesenchymal transition (EMT) of EOC cell lines under hypoxia <jats:italic>in vitro.<\/jats:italic> We also investigated the possible mechanism underlying it. The results showed that sohlh2 inhibited the migration, invasion and EMT of EOC cells and might function through suppression of the hypoxia-inducible factor 1\u03b1 (HIF1\u03b1)\/carbonic anhydrase 9 (CA9) signaling pathway. Our results may open a new avenue for the further development of diagnostic tools and novel therapeutics that will benefit EOC patients.<\/jats:p>","DOI":"10.1515\/hsz-2019-0119","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T09:02:22Z","timestamp":1563440542000},"page":"263-271","source":"Crossref","is-referenced-by-count":8,"title":["Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1\u03b1\/CA9 signaling pathway"],"prefix":"10.1515","volume":"401","author":[{"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , 44 Wenhua Xi Road , Jinan, Shandong 250012 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"2023040406510881302_j_hsz-2019-0119_ref_001_w2aab3b7c15b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ahmed, N. and Stenvers, K.L. (2013). Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research. Front. Oncol. 3, 256.","DOI":"10.3389\/fonc.2013.00256"},{"key":"2023040406510881302_j_hsz-2019-0119_ref_002_w2aab3b7c15b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Ballow, D.J., Xin, Y., Choi, Y., Pangas, S.A., and Rajkovic, A. (2006). Sohlh2 is a germ cell-specific bHLH transcription factor. Gene Expr. 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