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Additionally, expression of Hes1 and Notch1 in HSCs co-cultured with BMSCs increased significantly at both protein and mRNA levels. Blocking of the notch signaling pathway (NSP) either by Notch1 siRNA or by DAPT treatment increased the proliferation rate while decreasing apoptosis and led to activation of the NF-\u03baB signaling pathway in HSCs co-cultured with BMSCs. These effects were found to be reversed in HSCs overexpressing I\u03baB S32\/S36 mutants. The Notch signaling-mediated cell-cell contact was partially involved in the significant inhibition of proliferation of HSCs by BMSCs. Additionally, the NF-\u03baB pathway was found to be responsible for NSP-mediated inhibition of growth of HSCs in the co-culture system. Thus, BMSCs might have a potential therapeutic significance in treating hepatic fibrosis.<\/jats:p>","DOI":"10.1515\/hsz-2019-0248","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T09:02:54Z","timestamp":1568710974000},"page":"505-515","source":"Crossref","is-referenced-by-count":4,"title":["Bone marrow-derived mesenchymal stem cells utilize the notch signaling pathway to induce apoptosis of hepatic stellate cells via NF-\u03baB sensor"],"prefix":"10.1515","volume":"401","author":[{"given":"Nan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Third Affiliated Hospital of Sun Yat-sen University , No. 600 Tianhe Road, Tianhe District , Guangzhou 510630, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Center , The Sixth Affiliated Hospital of Sun Yat-sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Third Affiliated Hospital of Sun Yat-sen University , No. 600 Tianhe Road, Tianhe District , Guangzhou 510630, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Third Affiliated Hospital of Sun Yat-sen University , No. 600 Tianhe Road, Tianhe District , Guangzhou 510630, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Third Affiliated Hospital of Sun Yat-sen University , No. 600 Tianhe Road, Tianhe District , Guangzhou 510630, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Kashi Affiliated Hospital of Sun Yat-sen University , Kashi , Xinjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobilliary Surgery , The Third Affiliated Hospital of Sun Yat-sen University , No. 600 Tianhe Road, Tianhe District , Guangzhou 510630, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"2023040406530205252_j_hsz-2019-0248_ref_001","doi-asserted-by":"crossref","unstructured":"Bai, F., Huang, Q., Nie, J., Lu, S., Lu, C., Zhu, X., Wang, Y., Zhuo, L., Lu, Z., and Lin, X. 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