{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:15:13Z","timestamp":1791983713097,"version":"4.4.0"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"10","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been reported that high-mobility group box 3 is overexpressed in various cancers. This study aimed to explore its function in non-small cell lung cancer (NSCLC). A546 and H460\u00a0cell lines were used for <jats:italic>in vivo<\/jats:italic> experiments, scratch healing tests, transwell migration and invasion experiments. It was first found that HMGB3 was highly expressed in tumor tissues in the patients and associated with NSCLC stage. Silencing of HMGB3 significantly slowed the growth, proliferation and invasion of NSCLC <jats:italic>in vitro<\/jats:italic>, and repressed cell growth <jats:italic>in vivo<\/jats:italic>. Mechanistic studies suggest that the observed effects were mediated by inhibiting the expression of \u03b2-catenin\/MMP7\/c-Myc in Wnt pathway. Our study highlights the role of HMGB3 in NSCLC, which may provide a therapeutic target for the treatment of NSCLC.<\/jats:p>","DOI":"10.1515\/hsz-2020-0144","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T13:34:51Z","timestamp":1594992891000},"page":"1191-1198","source":"Crossref","is-referenced-by-count":23,"title":["High-mobility group box 3 (HMGB3) silencing inhibits non-small cell lung cancer development through regulating Wnt\/\u03b2-catenin pathway"],"prefix":"10.1515","volume":"401","author":[{"given":"Yunjing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, PLA General Hospital, Beijing100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, PLA General Hospital, Beijing100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, PLA General Hospital, Beijing100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, PLA General Hospital, Beijing100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, PLA General Hospital, Beijing100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref471","first-page":"756","article-title":"Autophagy: in the hands of HMGB1","volume":"11","year":"2010","journal-title":"Nat. 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