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The formation of these insoluble aggregates has been linked with the death and dysfunction of \u03b2-cells. Therefore, hIAPP aggregation has been identified as a therapeutic target for T2DM management. Several natural products are now being investigated for their potential to inhibit hIAPP aggregation and\/or disaggregate preformed aggregates. In this study, we attempt to identify the anti-amyloidogenic potential of Myricetin (MYR)- a polyphenolic flavanoid, commonly found in fruits (like <jats:italic>Syzygium cumini<\/jats:italic>). Our results from biophysical studies indicated that MYR supplementation inhibits hIAPP aggregation and disaggregates preformed fibrils into non-toxic species. This protection was accompanied by inhibition of oxidative stress, reduction in lipid peroxidation and the associated membrane damage and restoration of mitochondrial membrane potential in INS-1E cells. MYR supplementation also reversed the loss of functionality in hIAPP exposed pancreatic islets via restoration of glucose-stimulated insulin secretion. Molecular dynamics simulation studies suggested that MYR molecules interact with the hIAPP pentameric fibril model at the amyloidogenic core region and thus prevents aggregation and distort the fibrils.<\/jats:p>","DOI":"10.1515\/hsz-2020-0176","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T09:46:04Z","timestamp":1600249564000},"page":"179-194","source":"Crossref","is-referenced-by-count":33,"title":["Myricetin protects pancreatic \u03b2-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function"],"prefix":"10.1515","volume":"402","author":[{"given":"Richa","family":"Dubey","sequence":"first","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, 400076Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti H.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, 411007Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath Chandra","family":"Dantu","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, 400076Mumbai, Maharashtra, India"},{"name":"Department of Computer Science, Brunel University London, UB83PHUxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajlaxmi","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, 400076Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika M.","family":"Sardesai","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, 411007Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, 400076Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhankar D.","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Zoology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, 411007Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetender","family":"Chugh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Science Education and Research, Homi Bhabha Road, Pashan, 411008Pune, India"},{"name":"Department of Biology, Indian Institute of Science Education and Research, Homi Bhabha Road, Pashan, 411008Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpy","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, 411007Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, 400076Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1091","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2353\/ajpath.2009.090417","article-title":"Phenolic compounds prevent Alzheimer\u2019s pathology through different effects on the amyloid-\u03b2 aggregation pathway","volume":"175","year":"2009","journal-title":"Am. 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