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Anti-bacterial and anti-biofilm assays demonstrated that selenocystine inhibits the growth of bacteria in their planktonic state, and formation of biofilms while eradicating preformed-biofilm effectively. Selenocystine at a MIC<jats:sub>50<\/jats:sub> as low as 42 and 28\u00a0\u03bcg\/mL effectively inhibited the growth of <jats:italic>Klebsiella pneumonia<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. The antibacterial effect is further reconfirmed by agar cup diffusion assay and growth-kill assay. Selenocystine showed 30\u201360% inhibition of biofilm formation in <jats:italic>K.\u00a0pneumonia,<\/jats:italic> and 44\u201370% in <jats:italic>P.\u00a0aeruginosa<\/jats:italic> respectively. It also distorted the preformed-biofilms by degrading the eDNA component of the Extracellular Polymeric Substance matrix. Molecular docking studies of selenocystine with quorum sensing specific proteins clearly showed that through the carboxylic acid moiety it interacts and inhibits the protein function, thereby confirming its anti-biofilm potential. With further validation selenocystine can be explored as a potential candidate for the treatment of RTIs.<\/jats:p>","DOI":"10.1515\/hsz-2020-0375","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T21:10:30Z","timestamp":1616101830000},"page":"769-783","source":"Crossref","is-referenced-by-count":13,"title":["Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: <i>in vitro<\/i> and <i>in silico<\/i> studies"],"prefix":"10.1515","volume":"402","author":[{"given":"Bharti","family":"Patel","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Sciences, UM DAE Centre for Excellence in Basic Sciences, University of Mumbai , Kalina Campus, Santacruz East , Mumbai 400098 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrata","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences, UM DAE Centre for Excellence in Basic Sciences, University of Mumbai , Kalina Campus, Santacruz East , Mumbai 400098 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-0272","authenticated-orcid":false,"given":"Indira K.","family":"Priyadarsini","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences, UM DAE Centre for Excellence in Basic Sciences, University of Mumbai , Kalina Campus, Santacruz East , Mumbai 400098 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirisha L.","family":"Vavilala","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences, UM DAE Centre for Excellence in Basic Sciences, University of Mumbai , Kalina Campus, Santacruz East , Mumbai 400098 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2023040406515606877_j_hsz-2020-0375_ref_002_w2aab3b7c71b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Ahmad, A., Viljoen, A.M., and Chenia, H.F. 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