{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:51:21Z","timestamp":1793346681078,"version":"4.5.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"6","funder":[{"name":"Guangdong Medical Science and technology research fund project","award":["A2022115"],"award-info":[{"award-number":["A2022115"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760057"],"award-info":[{"award-number":["81760057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNA (miR)-143-3p is a potential regulatory molecule in myocardial ischemia\/reperfusion injury (MI\/RI), wherein its expression and pathological effects remains controversial. Thus, a mouse MI\/RI and cell hypoxia\/reoxygenation (<jats:italic>H<\/jats:italic>\/<jats:italic>R<\/jats:italic>) models were built for clarifying the miR-143-3p\u2019s role in MI\/RI. Following myocardial ischemia for 30\u00a0min,\u00a0mice underwent reperfusion for 3, 6, 12 and 24\u00a0h. It\u00a0was found miR-143-3p increased in the ischemic heart tissue over\u00a0time after reperfusion. Cardiomyocytes transfected with miR-143-3p were more susceptible to apoptosis. Mechanistically, miR-143-3p targeted B\u00a0cell lymphoma 2 (bcl-2). And miR-143-3p inhibition reduced cardiomyocytes apoptosis upon <jats:italic>H<\/jats:italic>\/<jats:italic>R<\/jats:italic>, whereas it was reversed by a specific bcl-2 inhibitor ABT-737. Of note, miR-143-3p inhibition upregulated bcl-2 with better mitochondrial membrane potential (\u0394\u03c8m), reduced cytoplasmic cytochrome c (cyto-c) and caspase proteins, and minimized infarction area in mice upon I\/R. Collectively, inhibition of miR-143-3p might alleviate MI\/RI via targeting bcl-2 to limit mitochondria-mediated apoptosis. To our knowledge, this study further clarifies the miR-143-3p\u2019s pathological role in the early stages of MI\/RI, and inhibiting miR-143-3p could be an effective treatment for ischemic myocardial disease.<\/jats:p>","DOI":"10.1515\/hsz-2022-0334","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T18:20:50Z","timestamp":1676312450000},"page":"619-631","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis"],"prefix":"10.1515","volume":"404","author":[{"given":"Chuang-Hong","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation , The First Affiliated Hospital of Guangxi Medical University , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Jiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Scripps Research Institute , No.10550 North Torrey Pines Road , La Jolla , CA 92037 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-shi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ying","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-You","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Zhuhai City People\u2019s Hospital , No.79 Kangning Road , Zhuhai 519050 , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"2023051015420527040_j_hsz-2022-0334_ref_001","doi-asserted-by":"crossref","unstructured":"Al-Salam, S. and Hashmi, S. 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