{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:14:26Z","timestamp":1791893666261,"version":"4.3.4"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81760057"],"award-info":[{"award-number":["81760057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Innovative Research Team Project of Guangxi Natural Science Foundation","award":["2018GXNSFGA281006"],"award-info":[{"award-number":["2018GXNSFGA281006"]}]},{"name":"\u2018139\u2019 Plan for Training High-level Medical Talents of Guangxi","award":["G201903007"],"award-info":[{"award-number":["G201903007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with acute myocardial infarction complicated with diabetes are more likely to develop myocardial ischemia\/reperfusion (I\/R) injury (MI\/RI) during reperfusion therapy. Both HMGB1 and RAGE play important roles in MI\/RI. However, the specific mechanisms of HMGB1 associated with RAGE are not fully clarified in diabetic MI\/RI. This study aimed to investigate whether the HMGB1-RAGE axis induces diabetic MI\/RI via regulating autophagy and apoptosis. A db\/db mouse model of MI\/RI was established, where anti-HMGB1 antibody and RAGE inhibitor (FPS-ZM1) were respectively injected after 10\u202fmin of reperfusion. The results showed that treatment with anti-HMGB1 significantly reduced the infarct size, serum LDH, and CK-MB level. Similar situations also occurred in mice administrated with FPS-ZM1, though the HMGB1 level was unchanged. Then, we found that treatment with anti-HMGB1 or FPS-ZM1 performed the same effects in suppressing the autophagy and apoptosis, as reflected by the results of lower LAMP2 and LC3B levels, increased Bcl-2 level, reduced BAX and caspase-3 levels. Moreover, the Pink1\/Parkin levels were also inhibited at the same time. Collectively, this study indicates that the HMGB1-RAGE axis aggravated diabetic MI\/RI via apoptosis and Pink1\/Parkin mediated autophagy pathways, and inhibition of HMGB1 or RAGE contributes to alleviating those adverse situations.<\/jats:p>","DOI":"10.1515\/hsz-2023-0134","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T17:24:15Z","timestamp":1695921855000},"page":"167-176","source":"Crossref","is-referenced-by-count":25,"title":["HMGB1-RAGE axis contributes to myocardial ischemia\/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice"],"prefix":"10.1515","volume":"405","author":[{"given":"De-Wei","family":"He","sequence":"first","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Zhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The Second Affiliated Hospital of Hainan Medical University , 368 Yihai Avenue , Haikou 570216 , Hainan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Scripps Research Institute , No.10550 North Torrey Pines Road , La Jolla , CA 92037 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases , No.6 Shuangyong Road , Nanning 530021 , Guangxi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"2024030110432748960_j_hsz-2023-0134_ref_001","doi-asserted-by":"crossref","unstructured":"Andrassy, M., Volz, H.C., Igwe, J.C., Funke, B., Eichberger, S.N., Kaya, Z., Buss, S., Autschbach, F., Pleger, S.T., Lukic, I.K., et al.. (2008). High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 117: 3216\u20133226, https:\/\/doi.org\/10.1161\/circulationaha.108.769331.","DOI":"10.1161\/CIRCULATIONAHA.108.769331"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_002","doi-asserted-by":"crossref","unstructured":"Chen, C., Lu, C., He, D., Na, N., Wu, Y., Luo, Z., and Huang, F. (2021). Inhibition of HMGB1 alleviates myocardial ischemia\/reperfusion injury in diabetic mice via suppressing autophagy. Microvasc. Res. 138: 104204, https:\/\/doi.org\/10.1016\/j.mvr.2021.104204.","DOI":"10.1016\/j.mvr.2021.104204"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_004","doi-asserted-by":"crossref","unstructured":"Cui, L., Zhao, L.P., Ye, J.Y., Yang, L., Huang, Y., Jiang, X.P., Zhang, Q., Jia, J.Z., Zhang, D.X., and Huang, Y. (2020). The lysosomal membrane protein Lamp2 alleviates lysosomal cell death by promoting autophagic flux in ischemic cardiomyocytes. Front. Cell. Dev. Biol. 8: 31, https:\/\/doi.org\/10.3389\/fcell.2020.00031.","DOI":"10.3389\/fcell.2020.00031"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_005","doi-asserted-by":"crossref","unstructured":"Delbridge, L.M.D., Mellor, K.M., Taylor, D.J., and Gottlieb, R.A. (2017). Myocardial stress and autophagy: mechanisms and potential therapies. Nat. Rev. Cardiol. 14: 412\u2013425, https:\/\/doi.org\/10.1038\/nrcardio.2017.35.","DOI":"10.1038\/nrcardio.2017.35"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_006","doi-asserted-by":"crossref","unstructured":"Dewanjee, S., Vallamkondu, J., Kalra, R., John, A., Reddy, P., and Kandimalla, R.J.A. (2021). Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy. Ageing Res. Rev. 68: 101338, https:\/\/doi.org\/10.1016\/j.arr.2021.101338.","DOI":"10.1016\/j.arr.2021.101338"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_007","doi-asserted-by":"crossref","unstructured":"Gan, L., Xie, D., Liu, J., Bond Lau, W., Christopher, T.A., Lopez, B., Zhang, L., Gao, E., Koch, W., Ma, X.L., et al.. (2020). Small extracellular microvesicles mediated pathological communications between dysfunctional adipocytes and cardiomyocytes as a novel mechanism exacerbating ischemia\/reperfusion injury in diabetic mice. Circulation 141: 968\u2013983, https:\/\/doi.org\/10.1161\/circulationaha.119.042640.","DOI":"10.1161\/CIRCULATIONAHA.119.042640"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_008","doi-asserted-by":"crossref","unstructured":"Guan, L., Che, Z., Meng, X., Yu, Y., Li, M., Yu, Z., Shi, H., Yang, D., and Yu, M.J.J. (2019). MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain\/OPA-1-mediated mitochondrial fusion\/mitophagy Inhibition. J.\u00a0Cell. Mol. Med. 23: 7830\u20137843, https:\/\/doi.org\/10.1111\/jcmm.14662.","DOI":"10.1111\/jcmm.14662"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_009","doi-asserted-by":"crossref","unstructured":"Hao, P., Liu, Y., Guo, H., Zhang, Z., Chen, Q., Hao, G., Zhang, C., and Zhang, Y.J.F. (2020). Prolylcarboxypeptidase mitigates myocardial ischemia\/reperfusion injury by stabilizing mitophagy. Front. Cell. Dev. Biol. 8: 584933, https:\/\/doi.org\/10.3389\/fcell.2020.584933.","DOI":"10.3389\/fcell.2020.584933"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_010","doi-asserted-by":"crossref","unstructured":"Lecour, S., Andreadou, I., B\u00f8tker, H., Davidson, S., Heusch, G., Ruiz-Meana, M., Schulz, R., Zuurbier, C., Ferdinandy, P., Hausenloy, D., et al.. (2021). Improving preclinical assessment of cardioprotective therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST action. Basic Res. Cardiol. 116: 52, https:\/\/doi.org\/10.1007\/s00395-021-00893-5.","DOI":"10.1007\/s00395-021-00893-5"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_011","doi-asserted-by":"crossref","unstructured":"Li, Q., Xu, M., Li, Z., Li, T., Wang, Y., Chen, Q., Wang, Y., Feng, J., Yin, X., and Lu, C. (2021). Maslinic acid attenuates ischemia\/reperfusion injury-induced myocardial inflammation and apoptosis by\u00a0regulating HMGB1-TLR4 axis. Front. Cardiovasc. Med. 8: 768947, https:\/\/doi.org\/10.3389\/fcvm.2021.768947.","DOI":"10.3389\/fcvm.2021.768947"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_012","doi-asserted-by":"crossref","unstructured":"Liu, W., Chen, C., Gu, X., Zhang, L., Mao, X., Chen, Z., and Tao, L. (2021). AM1241 alleviates myocardial ischemia-reperfusion injury in rats by enhancing Pink1\/Parkin-mediated autophagy. Life Sci. 272: 119228, https:\/\/doi.org\/10.1016\/j.lfs.2021.119228.","DOI":"10.1016\/j.lfs.2021.119228"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_013","doi-asserted-by":"crossref","unstructured":"Ma, W., Guo, W., Shang, F., Li, Y., Li, W., Liu, J., Ma, C., and Teng, J. (2020). Bakuchiol alleviates hyperglycemia-induced diabetic cardiomyopathy by reducing myocardial oxidative stress via activating the SIRT1\/Nrf2 signaling pathway. Oxid. Med. Cell. Longev. 2020: 3732718, https:\/\/doi.org\/10.1155\/2020\/3732718.","DOI":"10.1155\/2020\/3732718"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_014","doi-asserted-by":"crossref","unstructured":"Nah, J., Zhai, P., Huang, C.Y., Fernandez, A.F., Mareedu, S., Levine, B., and Sadoshima, J. (2020). Upregulation of Rubicon promotes autosis during myocardial ischemia\/reperfusion injury. J.\u00a0Clin. Invest. 130: 2978\u20132991, https:\/\/doi.org\/10.1172\/jci132366.","DOI":"10.1172\/JCI132366"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_015","doi-asserted-by":"crossref","unstructured":"Quinn, P.M.J., Moreira, P.I., Ambrosio, A.F., and Alves, C.H. (2020). PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation. Acta Neuropathol. Commun. 8: 189, https:\/\/doi.org\/10.1186\/s40478-020-01062-w.","DOI":"10.1186\/s40478-020-01062-w"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_016","doi-asserted-by":"crossref","unstructured":"Ramasamy, R., Yan, S.F., and Schmidt, A.M. (2008). Stopping the primal RAGE reaction in myocardial infarction: capturing adaptive responses to heal the heart? Circulation 117: 3165\u20133167, https:\/\/doi.org\/10.1161\/circulationaha.108.784397.","DOI":"10.1161\/CIRCULATIONAHA.108.784397"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_017","doi-asserted-by":"crossref","unstructured":"Raucci, A., Di Maggio, S., Scavello, F., D\u2019Ambrosio, A., Bianchi, M.E., and Capogrossi, M.C. (2019). The Janus face of HMGB1 in heart disease: a\u00a0necessary update. Cell. Mol. Life Sci. 76: 211\u2013229, https:\/\/doi.org\/10.1007\/s00018-018-2930-9.","DOI":"10.1007\/s00018-018-2930-9"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_018","doi-asserted-by":"crossref","unstructured":"Shi, X., Li, Y., Wang, Y., Ding, T., Zhang, X., and Wu, N. (2021). Pharmacological postconditioning with sappanone A ameliorates myocardial ischemia reperfusion injury and mitochondrial dysfunction via AMPK-mediated mitochondrial quality control. Toxicol. Appl. Pharmacol. 427: 115668, https:\/\/doi.org\/10.1016\/j.taap.2021.115668.","DOI":"10.1016\/j.taap.2021.115668"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_019","doi-asserted-by":"crossref","unstructured":"Shires, S.E. and Gustafsson, A.B. (2015). Mitophagy and heart failure. J.\u00a0Mol. Med. 93: 253\u2013262, https:\/\/doi.org\/10.1007\/s00109-015-1254-6.","DOI":"10.1007\/s00109-015-1254-6"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_020","doi-asserted-by":"crossref","unstructured":"Shires, S.E. and Gustafsson, A.B. (2018). Regulating renewable energy: connecting AMPK\u03b12 to PINK1\/Parkin-mediated mitophagy in the heart. Circ. Res. 122: 649\u2013651, https:\/\/doi.org\/10.1161\/circresaha.118.312655.","DOI":"10.1161\/CIRCRESAHA.118.312655"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_021","doi-asserted-by":"crossref","unstructured":"Volz, H.C., Seidel, C., Laohachewin, D., Kaya, Z., Muller, O.J., Pleger, S.T., Lasitschka, F., Bianchi, M.E., Remppis, A., Bierhaus, A., et al.. (2010). HMGB1: the missing link between diabetes mellitus and heart failure. Basic Res. Cardiol. 105: 805\u2013820, https:\/\/doi.org\/10.1007\/s00395-010-0114-3.","DOI":"10.1007\/s00395-010-0114-3"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_022","doi-asserted-by":"crossref","unstructured":"Xia, J.Y., Chen, C., Lin, Q., Cui, J., Wan, J., Li, Y., and Li, D. (2023). Role of mitophagy in myocardial ischemia\/reperfusion injury and Chinese medicine treatment. Chin. J.\u00a0Integr. Med. 29: 81\u201388, https:\/\/doi.org\/10.1007\/s11655-021-3301-1.","DOI":"10.1007\/s11655-021-3301-1"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_023","doi-asserted-by":"crossref","unstructured":"Xiong, W., Zhou, R., Qu, Y., Yang, Y., Wang, Z., Song, N., Liang, R., and Qian, J. (2021). Dexmedetomidine preconditioning mitigates myocardial ischemia\/reperfusion injury via inhibition of mast cell degranulation. Biomed. Pharmacother. 141: 111853, https:\/\/doi.org\/10.1016\/j.biopha.2021.111853.","DOI":"10.1016\/j.biopha.2021.111853"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_024","doi-asserted-by":"crossref","unstructured":"Yu, S.Y., Dong, B., Fang, Z.F., Hu, X.Q., Tang, L., and Zhou, S.H. (2018). Knockdown of lncRNA AK139328 alleviates myocardial ischaemia\/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy. J.\u00a0Cell. Mol. Med. 22: 4886\u20134898, https:\/\/doi.org\/10.1111\/jcmm.13754.","DOI":"10.1111\/jcmm.13754"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_025","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhai, M., Li, B., Liu, Z., Li, K., Jiang, L., Zhang, M., Yi, W., Yang, J., Yi, D., et al.. (2018). Honokiol ameliorates myocardial ischemia\/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway. Oxid. Med. Cell. Longev. 2018: 3159801, https:\/\/doi.org\/10.1155\/2018\/3159801.","DOI":"10.1155\/2018\/3159801"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_026","doi-asserted-by":"crossref","unstructured":"Zhang, D., He, Y., Ye, X., Cai, Y., Xu, J., Zhang, L., Li, M., Liu, H., Wang, S., and Xia, Z. (2020a). Activation of autophagy inhibits nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic rats. J.\u00a0Diabetes Invest. 11: 1126\u20131136, https:\/\/doi.org\/10.1111\/jdi.13235.","DOI":"10.1111\/jdi.13235"},{"key":"2024030110432748960_j_hsz-2023-0134_ref_027","doi-asserted-by":"crossref","unstructured":"Zhang, Y.J., Zhang, M., Zhao, X., Shi, K., Ye, M., Tian, J., Guan, S., Ying, W., and Qu, X. (2020b). NAD+ administration decreases microvascular damage following cardiac ischemia\/reperfusion by restoring autophagic flux. Basic Res. Cardiol. 115: 57, https:\/\/doi.org\/10.1007\/s00395-020-0817-z.","DOI":"10.1007\/s00395-020-0817-z"}],"container-title":["Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2023-0134\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2023-0134\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:43:53Z","timestamp":1709289833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2023-0134\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,28]]},"published-print":{"date-parts":[[2024,3,25]]}},"alternative-id":["10.1515\/hsz-2023-0134"],"URL":"https:\/\/doi.org\/10.1515\/hsz-2023-0134","relation":{},"ISSN":["1431-6730","1437-4315"],"issn-type":[{"value":"1431-6730","type":"print"},{"value":"1437-4315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}