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While prophylactic vaccines will alleviate the HPV disease burden on future generations, there are currently no\u00a0therapeutic anti-viral strategies for combating HPV infections or lesions. HPV induce the proliferation of infected epithelial cells and modulate the host differentiation response, and both of these controls are required for a successful viral life cycle. Enhanced understanding of viral-host interactions during the viral life cycle will identify potential novel anti-viral strategies for therapeutic development. This minireview will summarize the critical role of the host enzyme CK2 in regulating the function of the viral proteins E1, E2 and E7; such control makes CK2 a critical enzyme for regulating HPV life cycles. Therapeutic strategies blocking CK2 function to combat HPV infections and treat HPV diseases will be described.<\/jats:p>","DOI":"10.1515\/hsz-2024-0150","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T16:56:34Z","timestamp":1746118594000},"page":"81-88","source":"Crossref","is-referenced-by-count":3,"title":["CK2 control of human papillomavirus life cycles"],"prefix":"10.1515","volume":"406","author":[{"given":"Apurva T.","family":"Prabhakar","sequence":"first","affiliation":[{"name":"6889 Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond , VA 23298 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4949-3032","authenticated-orcid":false,"given":"Iain M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"6889 Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond , VA 23298 , USA"},{"name":"6889 Virginia Commonwealth University Massey Cancer Center , Richmond , VA 23298 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"2026011115150402082_j_hsz-2024-0150_ref_001","doi-asserted-by":"crossref","unstructured":"Ang, K.K., Harris, J., Wheeler, R., Weber, R., Rosenthal, D.I., Nguyen-T\u00e3\u00a2N, P.F., Westra, W.H., Chung, C.H., Jordan, R.C., Lu, C., et al.. (2010). Human papillomavirus and survival of patients with oropharyngeal cancer. New Engl. J.\u00a0Med. 363: 24\u201335, https:\/\/doi.org\/10.1056\/nejmoa0912217.","DOI":"10.1056\/NEJMoa0912217"},{"key":"2026011115150402082_j_hsz-2024-0150_ref_002","doi-asserted-by":"crossref","unstructured":"Basukala, O., Mittal, S., Massimi, P., Bestagno, M., and Banks, L. (2019). The HPV-18 E7 CKII phospho acceptor site is required for maintaining the transformed phenotype of cervical tumour-derived cells. PLoS Pathog. 15: e1007769, https:\/\/doi.org\/10.1371\/journal.ppat.1007769.","DOI":"10.1371\/journal.ppat.1007769"},{"key":"2026011115150402082_j_hsz-2024-0150_ref_003","doi-asserted-by":"crossref","unstructured":"Basukala, O., Trejo-Cerro, O., Myers, M.P., Pim, D., Massimi, P., Thomas, M., Guarnaccia, C., Owen, D., and Banks, L. (2022). 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