{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:22:33Z","timestamp":1773926553264,"version":"3.50.1"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recent studies have identified A\u03b2 peptides in human gut epithelial cells, along with several amyloid-forming proteins and peptides in the gut lumen. These findings suggest that A\u03b2 or other amyloid-like molecules originating from the gut may contribute to the involvement of the gastrointestinal system in the development of Alzheimer\u2019s disease (AD) pathology. Modulating the aggregation behaviour of A\u03b2 and other amyloid forming peptides\/proteins present in the gut may represent novel strategy to mitigate AD pathology. This study explores the use of Milk-derived Amyloid-like Protein Aggregates (MAPA) to inhibit A\u03b2(40) aggregation\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    . MAPA\u2019s inhibitory effects were assessed using amyloid dye-binding assays (Thioflavin T, Congo Red, and ANS) and transmission electron microscopy. Toxicity assays showed that the MAPA significantly reduced A\u03b2(40)-induced neuronal death. Fluorescence quenching suggest MAPA physically interacts with A\u03b2(40) to prevent its aggregation. By blocking A\u03b2 aggregation and reducing its neurotoxicity, MAPA presents a promising organic strategy to counteract AD progression influenced by gut factors. These findings open new avenues for AD prevention and the disease management, especially via dietary interventions targeting the gastro-intestinal system.\n                  <\/jats:p>","DOI":"10.1515\/hsz-2025-0208","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:49:48Z","timestamp":1773913788000},"source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of A\u03b2(40) peptide aggregation by Milk-derived Amyloid-like Protein Aggregates (MAPA)"],"prefix":"10.1515","author":[{"given":"Shweta","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indranil","family":"De","sequence":"additional","affiliation":[{"name":"Institute of Nano Science and Technology , 140306 Mohali , Punjab , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikash","family":"Poonia","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritika","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute of Nano Science and Technology , 140306 Mohali , Punjab , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-5925","authenticated-orcid":false,"given":"Jay Kant","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Central University of Rajasthan , NH-8 Bandersindri , 305817 Kishangarh, Ajmer , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"2026031909494314747_j_hsz-2025-0208_ref_001","doi-asserted-by":"crossref","unstructured":"Adamcik, J. and Mezzenga, R. 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