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An ever-expanding group of Golgins and multi-subunit tethering complexes assumes distinct functions in specific Golgi subcompartments in close partnership with Rab and ARL family GTPases. Their dysregulation or mutation impairs glycosylation, vesicle trafficking, and cytoskeletal dynamics, thereby contributing to a spectrum of human pathologies ranging from neurodegenerative disorders (e.g. Alzheimer\u2019s and Parkinson\u2019s disease) to cancers (e.g. lung, breast, colon) and metabolic defects (impaired insulin secretion and lipid droplet formation). Here, we review these diverse roles across molecular, cellular and organismal physiology.<\/jats:p>","DOI":"10.1515\/hsz-2025-0242","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:56:48Z","timestamp":1779721008000},"page":"199-216","source":"Crossref","is-referenced-by-count":1,"title":["Golgi-associated membrane scaffolds: roles in health and disease"],"prefix":"10.1515","volume":"407","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-0879","authenticated-orcid":false,"given":"Thilo","family":"Speckmann","sequence":"first","affiliation":[{"name":"Department of Experimental Diabetology , German Institute of Human Nutrition (DIfE) Potsdam-Rehbr\u00fccke , Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal , Germany"},{"name":"German Center for Diabetes Research (DZD) , Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4293-0591","authenticated-orcid":false,"given":"Judith","family":"Saurenbach","sequence":"additional","affiliation":[{"name":"Department of Experimental Diabetology , German Institute of Human Nutrition (DIfE) Potsdam-Rehbr\u00fccke , Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal , Germany"},{"name":"German Center for Diabetes Research (DZD) , Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-4377","authenticated-orcid":false,"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[{"name":"Department of Experimental Diabetology , German Institute of Human Nutrition (DIfE) Potsdam-Rehbr\u00fccke , Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal , Germany"},{"name":"German Center for Diabetes Research (DZD) , Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg , Germany"},{"name":"Institute of Nutritional Science , University of Potsdam , Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026080805591991207_j_hsz-2025-0242_ref_001","doi-asserted-by":"crossref","unstructured":"Ahat, E., Xiang, Y., Zhang, X., Bekier, M.E.2nd, and Wang, Y. 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